2. Gene
  3. ANGPTL8 - angiopoietin like 8 Gene

ANGPTL8 - angiopoietin like 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：血管生成素样 8

种属: Homo sapiens

同用名: RIFL; TD26; PRO1185; PVPA599; C19orf80

基因 ID: 55908 | 基因类型: protein coding

关于 ANGPTL8

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:11,239,619-11,241,943 (from NCBI)

This gene has 4 transcripts (splice variants) and 90 orthologues. Biased expression in liver (RPKM 32.5) and fat (RPKM 10.2).

功能概要

预测可使荷尔蒙活动。参与调节脂质代谢过程和甘油三酯稳态。在蛋白质加工和脂蛋白代谢过程调节的正向调节上游或内部起作用。位于胞外区。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable hormone activity. Involved in regulation of lipid metabolic process and triglyceride homeostasis. Acts upstream of or within positive regulation of protein processing and regulation of lipoprotein metabolic process. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

ANGPTL8 基因产物(1)

mRNA Protein Name
NM_018687.7 NP_061157.3 angiopoietin-like protein 8 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21988832 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of protein processing IDA
IDA: 通过直接分析推断
23150577 GOA
involved in regulation of lipid metabolic process IDA
IDA: 通过直接分析推断
25417115 GOA
acts upstream of or within regulation of lipoprotein metabolic process IMP
IMP: 通过突变表型推断
23150577 GOA
involved in triglyceride homeostasis IDA
IDA: 通过直接分析推断
25417115 GOA
acts upstream of or within triglyceride homeostasis IGI
IGI: 通过遗传相互作用推断
23150577 GOA
NOT involved in type B pancreatic cell proliferation IDA
IDA: 通过直接分析推断
25417115 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
23150577 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

angiopoietin-like protein 8

hepatocellular carcinoma-associated gene TD26

ANGPTL8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ANGPTL8 Q6UXH0 RCHY1 Homo sapiens Q96PM5
Anti Tag CoIP
21988832
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ANGPTL8 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7506 ANGPTL8/Angiopoietin-like 8 Protein, Human (HEK293, Fc) Q6UXH0 (A22-A198) ≥95%

关联疾病

疾病名称 别名
Hypobetalipoproteinemia, Familial, 2

Familial Hypobetalipoproteinemia 2

FHBL2

Hypolipidemia, Familial, Combined

Combined Familial Hypolipidemia

Combined Hypobetalipoproteinemia Familial

Hypobetalipoproteinemia, Familial, Type 2
Diabetes Mellitus

Diabetes
Familial Hyperlipidemia

Familial Hyperlipoproteinemia

Hyperlipidaemia

Hyperlipoproteinemias

Hyperlipidemia

Hyperlipemia

Hyperlipidemias
Non-Alcoholic Fatty Liver Disease

Fatty Liver

Non-Alcoholic Fatty Liver

Nafld

Nonalcoholic Fatty Liver Disease

Nonalcoholic Steatohepatitis

Steatosis

Nafl

Nash

Non-Alcoholic Steatohepatitis

Susceptibility To Nonalcoholic Fatty Liver Disease

Steatohepatitis

Fatty Degeneration

Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

Nafld Without Nash

Nafld Without Mention Of Nash
Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome

PWS

Willi-Prader Syndrome

Prader-Willi Syndrome Due To Translocation

Prader-Willi Syndrome Due To Imprinting Mutation

Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

Prader Willi Syndrome

Upd(15)Mat
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Spinal Muscular Atrophy, Type Iii

SMA3

Juvenile Spinal Muscular Atrophy

Kugelberg-Welander Disease

Sma Iii

Kugelberg-Welander Syndrome

Kws

Muscular Atrophy, Juvenile

Spinal Muscular Atrophy, Mild Childhood And Adolescent Form

Spinal Muscular Atrophy-3

Spinal Muscular Atrophy Type 3

Spinal Muscular Atrophy, Type Iii, Modifier Of

Type Iii Spinal Muscular Atrophy

Sma 3

Proximal Spinal Muscular Atrophy Type 3

Sma Type 3

Sma Type Iii

Sma-Iii

Spinal Muscular Atrophy 3

Spinal Muscular Atrophy Mild Childhood And Adolescent Form

Spinal Muscular Atrophy Type Iii

Wohlfart-Kugelberg-Welander Disease

Atrophy, Muscular, Spinal, Type Iii
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00697 ANGPTL8 Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990336 Anti-ANGPTL8 Antibody / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ANGPTL8 MGD MGI:3643534
Rattus norvegicus ANGPTL8 RGD RGD:2320121
Macaca mulatta ANGPTL8 VGNC VGNC:69691
Canis familiaris ANGPTL8 VGNC VGNC:37864
Bos taurus ANGPTL8 VGNC VGNC:25896
Felis catus ANGPTL8 VGNC VGNC:69346
Others ANGPTL8 NCBI
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