2. Gene
  3. BID - BH3 interacting domain death agonist Gene

BID - BH3 interacting domain death agonist Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：BH3 相互作用域死亡激动因子

种属: Homo sapiens

同用名: FP497

基因 ID: 637 | 基因类型: protein coding

关于 BID

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:17,734,138-17,774,665 (from NCBI)

This gene has 11 transcripts (splice variants) and 90 orthologues. Ubiquitous expression in bone marrow (RPKM 13.8), brain (RPKM 9.4) and 24 other tissues.

功能概要

该基因编码与激动剂 Bax 或拮抗剂 BCL2 异二聚化的死亡激动剂，从而调节细胞凋亡。编码的蛋白质是 Bcl-2 细胞死亡调节剂家族的成员。它是 Caspase-8 (CASP8) 诱导的线粒体损伤的介质； CASP8 切割这种编码的蛋白质，COOH 末端部分转移到线粒体，在那里它触发细胞色素 c 的释放。已发现多个选择性剪接的转录本变体。[RefSeq 提供，2020 年 8 月]

This gene encodes a death agonist that heterodimerizes with either agonist Bax or antagonist BCL2, and thus regulate Apoptosis. The encoded protein is a member of the Bcl-2 Family of cell death regulators. It is a mediator of mitochondrial damage induced by Caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Aug 2020]

BID 基因产物(7)

mRNA Protein Name
NM_001196.4 NP_001187.1 BH3-interacting domain death agonist isoform 2
NM_001244567.1 NP_001231496.1 BH3-interacting domain death agonist isoform 2
NM_001244569.1 NP_001231498.1 BH3-interacting domain death agonist isoform 3
NM_001244570.1 NP_001231499.1 BH3-interacting domain death agonist isoform 3
NM_001244572.1 NP_001231501.1 BH3-interacting domain death agonist isoform 3
NM_197966.3 NP_932070.1 BH3-interacting domain death agonist isoform 1
NM_197967.2 NP_932071.1 BH3-interacting domain death agonist isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9463381 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in establishment of protein localization to membrane IDA
IDA: 通过直接分析推断
21041309 GOA
involved in hepatocyte apoptotic process IDA
IDA: 通过直接分析推断
32029622 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
17289999 GOA
involved in positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
21459798 GOA
involved in positive regulation of intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
21262771 GOA
involved in positive regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
19074440 GOA
involved in positive regulation of release of cytochrome c from mitochondria IDA
IDA: 通过直接分析推断
32029622 GOA
involved in positive regulation of release of cytochrome c from mitochondria IGI
IGI: 通过遗传相互作用推断
21041309 GOA
involved in positive regulation of release of cytochrome c from mitochondria IMP
IMP: 通过突变表型推断
17289999 GOA
involved in release of cytochrome c from mitochondria IDA
IDA: 通过直接分析推断
17052454 GOA
involved in supramolecular fiber organization IDA
IDA: 通过直接分析推断
33106313 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
29531808 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BID 蛋白结构

BID

BID: BH3 interacting domain (BID) (1 - 195)

  • 0
  • 100
  • 195 a.a.
蛋白主名 其他名称

BH3-interacting domain death agonist

Human BID coding sequence

重组 BID 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7662 BID Protein, Human P55957 (M1-D195) ≥95%

关联疾病

疾病名称 别名
Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Cervical Cancer

Cervical Cancer, Somatic

Neoplasm Of Uterine Cervix

Cervix Cancer

Uterine Cervical Neoplasm

Cervical Neoplasm

Cervix Uteri Cancer

Tumor Of The Cervix Uteri

CERCA

Uterine Cervical Cancer

Neoplasms Cervical

Uterine Cervical Neoplasms

Cervical Cancers

Cancer, Cervical, Somatic

Malignant Tumor Of Cervix

Cervix Carcinoma
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Clubfoot

Congenital Talipes Equinovarus

Congenital Clubfoot

Congenital Equinovarus

Equinovarus Deformity Of Foot

Club Foot
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0493 Niflumic acid Inhibitor 99.88% 否
Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10510 BI-D1870 99.72% 否
HY-103661 BI-6C9 Inhibitor 98.47% 否
HY-18601 (±)-BI-D Inhibitor 98.06% 否
HY-123244 YC137 / 否
HY-162642 Bfl-1-IN-3 Inhibitor / 否
HY-P10614 Bid BH3 peptide / 否
HY-P5325 Bid BH3 (80-99) / 否
HY-P5325F Bid BH3 (80-99), FAM labeled / 否
HY-P5327 r8 Bid BH3 / 否
HY-RS01502 BID Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-121200 Azadirone / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus BID VGNC VGNC:26496
Rattus norvegicus BID RGD RGD:620160
Felis catus BID VGNC VGNC:60115
Macaca mulatta BID VGNC VGNC:70250
Canis familiaris BID VGNC VGNC:38456
Mus musculus BID MGD MGI:108093
Others BID NCBI
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