2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. YC137

YC137 是一种有效的 Bcl-2 拮抗剂，在 Bis-Tris 缓冲液中测定，对 Bcl-2 和 Bcl-xL 的 Ki 值为 1.3 μM 和 >100 μM。YC137 抑制 Bid BH3 肽与 Bcl-2 的结合，从而破坏 Bcl-2 抗凋亡活性所必需的相互作用。YC137 选择性地诱导 Bcl-2 依赖性细胞的凋亡。YC137 具有用于乳腺癌研究的潜力。

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YC137 Chemical Structure

YC137 Chemical Structure

CAS No. : 810659-53-1

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YC137 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YC137 is a potent Bcl-2 antagonist with Kis of 1.3 μM and >100 μM for Bcl-2 and Bcl-xL when assayed in Bis-Tris buffer, respectively. YC137 inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. YC137 selectively induces apoptosis of Bcl-2-dependent cells. YC137 has the potential for breast cancer research[1][2].

IC50 & Target[1]

Bcl-2

1.3 μM (Ki)

Bcl-xL

>100 μM (Ki)

分子量

511.57

Formula

C24H21N3O6S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YC137 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YC137810659-53-1YC 137YC-137Bcl-2 FamilyApoptosisBid BH3antiapoptoticbreast cancerInhibitorinhibitorinhibit

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目录号：
HY-123244
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