2. Gene
  3. BCAN - brevican Gene

BCAN - brevican Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：简短的

种属: Homo sapiens

同用名: BEHAB; CSPG7

基因 ID: 63827 | 基因类型: protein coding

关于 BCAN

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,642,117-156,659,528 (from NCBI)

This gene has 8 transcripts (splice variants), 272 orthologues and 7 paralogues. Restricted expression toward brain (RPKM 121.6).

功能概要

该基因编码在中枢神经系统中特异性表达的硫酸软骨素蛋白多糖聚糖家族的成员。这种蛋白质在发育过程中受到调节，可能在大脑细胞外基质的形成中发挥作用。这种蛋白质在神经胶质瘤中高表达，可能促进脑肿瘤细胞的生长和细胞运动。交替剪接导致多个转录本变体。[RefSeq 提供，2011 年 9 月]

This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

BCAN 基因产物(2)

mRNA Protein Name
NM_021948.5 NP_068767.3 brevican core protein isoform 1 precursor
NM_198427.2 NP_940819.1 brevican core protein isoform 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BCAN 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (43 - 142)

Xlink

Xlink: Extracellular link domain (156 - 251)

Xlink

Xlink: Extracellular link domain (257 - 353)

EGF

EGF: EGF-like domain (650 - 679)

Lectin_C

Lectin_C: Lectin C-type domain (706 - 810)

Sushi

Sushi: Sushi repeat (SCR repeat) (815 - 871)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 911 a.a.
蛋白主名 其他名称

brevican core protein

brain-enriched hyaluronan-binding protein

BCAN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BCAN Q96GW7 LYN Homo sapiens P07948
Y2H Array
32814053
种属内
BCAN Q96GW7 LYN Homo sapiens P07948
Y2H Pooling
32814053
种属内
BCAN Q96GW7 LYN Homo sapiens P07948
Validated Y2H
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 BCAN 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7676 BCAN Protein, Human (HEK293, His) Q96GW7-1 (D23-P911) ≥95%

关联疾病

疾病名称 别名
Normal Pressure Hydrocephalus

Low Pressure Hydrocephalus

Hydrocephalus Normal Pressure

Hydrocephalus, Normal Pressure

Normal Pressure Hydrocephalus Nos

Nph - [Normal Pressure Hydrocephalus]

Normal Pressure Hydrocephaly
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01394 BCAN Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris BCAN VGNC VGNC:38395
Felis catus BCAN VGNC VGNC:60077
Mus musculus BCAN MGD MGI:1096385
Bos taurus BCAN VGNC VGNC:26434
Macaca mulatta BCAN VGNC VGNC:70112
Rattus norvegicus BCAN RGD RGD:2194
Others BCAN NCBI
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