EPS8L2 - EPS8 like 2 Gene

中文名称：EPS8 样 2

种属: Homo sapiens

同用名: EPS8R2; DFNB106

基因 ID: 64787 | 基因类型: protein coding

关于 EPS8L2

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:706,231-727,727 (from NCBI)

This gene has 31 transcripts (splice variants), 199 orthologues, 3 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 41.5), small intestine (RPKM 39.9) and 18 other tissues.

功能概要

该基因编码 EPS8 基因家族的成员。与该家族的其他成员一样，编码的蛋白质被认为将生长因子刺激与肌动蛋白组织联系起来，在调节肌动蛋白细胞骨架重塑的途径中产生功能冗余。[RefSeq 提供，2008 年 12 月]

This gene encodes a member of the EPS8 gene family. The encoded protein, like Other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008]

EPS8L2 基因产物(1)

mRNA	Protein	Name
NM_022772.4	NP_073609.2	epidermal growth factor receptor kinase substrate 8-like protein 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables actin binding	IDA IDA: 通过直接分析推断	14565974	GOA
contributes to guanyl-nucleotide exchange factor activity	IDA IDA: 通过直接分析推断	14565974	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14565974	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Rho protein signal transduction	IDA IDA: 通过直接分析推断	14565974	GOA
involved in positive regulation of ruffle assembly	IGI IGI: 通过遗传相互作用推断	14565974	GOA
involved in regulation of Rho protein signal transduction	IDA IDA: 通过直接分析推断	14565974	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of protein-containing complex	IDA IDA: 通过直接分析推断	14565974	GOA
located in ruffle membrane	IDA IDA: 通过直接分析推断	14565974	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EPS8L2 蛋白结构

PTB

SH3_1

0
200
400
600
715 a.a.

蛋白主名

其他名称

epidermal growth factor receptor kinase substrate 8-like protein 2

EPS8-related protein 2

EPS8L2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	EPS8L2	Q9H6S3	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	EPS8L2	Q9H6S3	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	EPS8L2	Q9H6S3	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	EPS8L2	Q9H6S3	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	EPS8L2	Q9H6S3	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	EPS8L2	Q9H6S3	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	EPS8L2	Q9H6S3	CTSD	Homo sapiens	P07339	Validated Y2H	32814053
Intra	EPS8L2	Q9H6S3	CTSD	Homo sapiens	P07339	Y2H Array	32814053
Intra	EPS8L2	Q9H6S3	CTSD	Homo sapiens	P07339	Y2H Pooling	32814053
Intra	EPS8L2	Q9H6S3	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	EPS8L2	Q9H6S3	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	EPS8L2	Q9H6S3	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	EPS8L2	Q9H6S3	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	EPS8L2	Q9H6S3	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	EPS8L2	Q9H6S3	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	EPS8L2	Q9H6S3	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	EPS8L2	Q9H6S3	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	EPS8L2	Q9H6S3	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	EPS8L2	Q9H6S3	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	EPS8L2	Q9H6S3	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	EPS8L2	Q9H6S3	GRN	Homo sapiens	P28799	Validated Y2H	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Deafness, Autosomal Recessive 106

DFNB106	Deafness Autosomal Recessive 106
Deafness, Autosomal Recessive, 106

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb	Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Deafness, Autosomal Dominant 67

DFNA67	Autosomal Dominant Nonsyndromic Deafness 67
Autosomal Dominant Deafness 67	Deafness, Autosomal Dominant, 67
Deafness, Autosomal Dominant, Type 67

Deafness, Autosomal Recessive 102

DFNB102	Autosomal Recessive Nonsyndromic Deafness 102
Autosomal Recessive Deafness 102	Deafness, Autosomal Recessive, 102
Deafness, Autosomal Recessive, Type 102

Autosomal Dominant Nonsyndromic Deafness 74

Dfna74

Deafness, Autosomal Dominant 68

DFNA68	Autosomal Dominant Nonsyndromic Deafness 68
Autosomal Dominant Deafness 68	Deafness, Autosomal Dominant, 68

Deafness, Autosomal Dominant 44

DFNA44	Autosomal Dominant Nonsyndromic Deafness 44
Autosomal Dominant Deafness 44	Deafness, Autosomal Dominant, 44
Deafness, Autosomal Dominant, Type 44

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Autosomal Dominant Nonsyndromic Deafness

Autosomal Dominant Deafness

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04456	EPS8L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	EPS8L2	VGNC	VGNC:61922
Rattus norvegicus	EPS8L2	RGD	RGD:1310912
Canis familiaris	EPS8L2	VGNC	VGNC:40429
Macaca mulatta	EPS8L2	VGNC	VGNC:72081
Mus musculus	EPS8L2	MGD	MGI:2138828
Bos taurus	EPS8L2	VGNC	VGNC:58372

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

EPS8L2 - EPS8 like 2 Gene

关于 EPS8L2

功能概要

EPS8L2 基因产物(1)

EPS8L2 蛋白结构

EPS8L2 蛋白互作信息

关联疾病

直系同源

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EPS8L2 - EPS8 like 2 Gene

关于 EPS8L2

功能概要

EPS8L2 基因产物(1)

EPS8L2 蛋白结构

EPS8L2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z