HTR7 - 5-hydroxytryptamine receptor 7 Gene

中文名称：5-羟色胺受体 7

种属: Rattus norvegicus

同用名: 5Ht7

关于 HTR7

功能概要

该基因编码的蛋白可启动 G 蛋白偶联血清素受体活性和神经递质受体活性。参与多个过程，包括腺苷酸环化酶激活血清素受体信号通路；检测涉及疼痛感觉的机械刺激；和化学突触传递的调节。位于几种细胞成分中，包括神经细胞体；粗面内质网;和突触小泡。是突触后膜的组成部分和突触前膜的组成部分。用于研究遗忘症；焦虑症;儿童失神性癫痫；认知障碍;和偏头痛。肠易激综合征的生物标志物。该基因的人类直系同源物与酒精使用障碍有关。与人类 HTR7（5-羟色胺受体 7）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating serotonin receptor signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Located in several cellular components, including neuronal cell body; rough endoplasmic reticulum; and synaptic vesicle. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study amnestic disorder; anxiety disorder; childhood absence epilepsy; cognitive disorder; and migraine. Biomarker of irritable bowel syndrome. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7). [provided by Alliance of Genome Resources, Apr 2022]