HTR7 - 5-hydroxytryptamine receptor 7 Gene

中文名称：5-羟色胺受体 7

种属: Homo sapiens

同用名: 5-HT7

基因 ID: 3363 | 基因类型: protein coding

关于 HTR7

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:90,740,823-90,858,039 (from NCBI)

This gene has 3 transcripts (splice variants), 221 orthologues and 8 paralogues. Biased expression in testis (RPKM 6.1), urinary bladder (RPKM 2.0) and 8 other tissues.

功能概要

神经递质血清素被认为在各种认知和行为功能中发挥作用。由该基因编码的血清素受体属于 G 蛋白偶联受体超家族，该基因是参与自闭症和其他神经精神疾病的候选位点。已经鉴定出三种剪接变体，它们编码的蛋白质的羧基末端长度不同。[RefSeq 提供，2008 年 7 月]

The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and Other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]

HTR7 基因产物(4)

mRNA	Protein	Name
NM_019860.4	NP_062874.1	5-hydroxytryptamine receptor 7 isoform b
XM_024447973.2	XP_024303741.1	5-hydroxytryptamine receptor 7 isoform X1
NM_000872.5	NP_000863.1	5-hydroxytryptamine receptor 7 isoform a
NM_019859.4	NP_062873.1	5-hydroxytryptamine receptor 7 isoform d

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G protein-coupled serotonin receptor activity	IDA IDA: 通过直接分析推断	8226867	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19486527	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in adenylate cyclase-activating serotonin receptor signaling pathway	IDA IDA: 通过直接分析推断	8226867	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in plasma membrane	IDA IDA: 通过直接分析推断	22448645	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HTR7 蛋白结构

7tm_1

0
100
200
300
400
479 a.a.

蛋白主名

其他名称

5-hydroxytryptamine receptor 7

5-HT-7	5-HT-X
5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)

HTR7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HTR7	P34969	MATR3	Homo sapiens	P43243	TAP	19486527
种属内	HTR7	P34969	MATR3	Homo sapiens	P43243	Crosslink	30021884

种属间: 跨种属相互作用 种属内: 同种属相互作用

HTR7 抗体

目录号	产品名	应用	反应物种
HY-P83051	HTR7 Antibody (YA2796)	WB	Human, Mouse, Rat

关联疾病

疾病名称

别名

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Irritable Bowel Syndrome

Irritable Colon	Psychogenic Ibs
Ibs - [Irritable Bowel Syndrome]	Spastic Bowel Syndrome

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Severe Congenital Neutropenia 8

Autosomal Dominant Severe Congenital Neutropenia 8 With Or Without Pancreatic Dysfunction And/Or Neurological Abnormalities	Scn8
Sdsl	Shwachman-Diamond Syndrome-Like

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Hymenolepiasis

Dwarf Tapeworm Infection	Hymenolepis Infectious Disease
Hymenolepsis Infection	Hyemolepis Nana Infection
Hymenolepiosis	Hymenolepis Infection
Dwarf Tapeworm	Hymenolepidosis
Hymenolepis Infestation

Acute Closed-Angle Glaucoma

Acute Angle-Closure Glaucoma

Oculogyric Crisis

Mental Depression

Depression

Depressive Disorder

Ischemic Colitis

Colitis, Ischemic

Irreversible Ischaemic Colitis

Bipolar I Disorder

Manic Depression Nos	Manic-Depressive Illness
Bipolar Disorder Nos

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06483	HTR7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06484	Htr7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06485	HTR7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	HTR7	VGNC	VGNC:30003
Rattus norvegicus	HTR7	RGD	RGD:71034
Mus musculus	HTR7	MGD	MGI:99841
Macaca mulatta	HTR7	VGNC	VGNC:106061
Felis catus	HTR7	VGNC	VGNC:67677
Canis familiaris	HTR7	VGNC	VGNC:41834

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