Pik3cb - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Gene

中文名称：磷脂酰肌醇 4 ,5-二磷酸 3-激酶催化亚基 β

种属: Mus musculus

同用名: p110beta; 1110001J02Rik

关于 Pik3cb

功能概要

该基因编码的蛋白可启动 1-磷脂酰肌醇-3-激酶活性和胰岛素受体底物结合活性。参与多个过程，包括磷脂酰肌醇 3-激酶信号传导；调节细胞内信号转导；和对缺血的反应。在几个过程的上游或内部起作用，包括伤口愈合中涉及的血管生成；胚胎分裂；和通过质膜粘附分子的嗜同细胞粘附。位于核内。以多种结构表达，包括早期胚胎；泌尿生殖系统；肝;呼吸系统;和脾脏。该基因的人类直系同源物与胶质母细胞瘤有关；前列腺癌；前列腺癌;和 2 型糖尿病。与人 PIK3CB（磷脂酰肌醇 4,5-二磷酸 3-激酶催化亚基 β）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 1-phosphatidylinositol-3-kinase activity and Insulin Receptor substrate binding activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; regulation of intracellular signal transduction; and response to ischemia. Acts upstream of or within several processes, including angiogenesis involved in wound healing; embryonic cleavage; and homophilic cell adhesion via plasma membrane adhesion molecules. Located in nucleus. Is expressed in several structures, including early embryo; genitourinary system; liver; respiratory system; and spleen. Human ortholog(s) of this gene implicated in glioblastoma; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]