1. Gene
  2. DEK - DEK proto-oncogene Gene

DEK - DEK proto-oncogene Gene

种属: Homo sapiens (human)

同用名: D6S231E

基因 ID: 7913 | 基因类型: protein coding

关于 DEK

功能概要

This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of Antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

DEK 基因产物(1)

mRNA Protein Name
XM_054356378.1 XP_054212353.1 protein DEK isoform X2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone binding IDA
IDA: 通过直接分析推断
12140263 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22113938 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase III IDA
IDA: 通过直接分析推断
16603771 GOA
acts upstream of or within regulation of double-strand break repair IMP
IMP: 通过突变表型推断
21653549 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of B-WICH complex IDA
IDA: 通过直接分析推断
16603771 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21653549 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

protein DEK

DEK oncogene (DNA binding)

DEK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DEK P35659 GPATCH11 Homo sapiens Q8N954-2
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Mus musculus DEK NCBI