BIRC7 - baculoviral IAP repeat containing 7 Gene

中文名称：含杆状病毒 IAP 重复 7

种属: Homo sapiens

同用名: KIAP; LIVIN; MLIAP; RNF50; ML-IAP

基因 ID: 79444 | 基因类型: protein coding

关于 BIRC7

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,235,905-63,240,495 (from NCBI)

This gene has 3 transcripts (splice variants), 156 orthologues and 7 paralogues. Biased expression in placenta (RPKM 3.1), skin (RPKM 0.7) and 5 other tissues.

功能概要

该基因编码凋亡抑制蛋白 (IAP) 家族的一个成员，并包含杆状病毒 IAP 重复序列 (BIR) 的单个拷贝以及 RING 型锌指结构域。 BIR 结构域对于抑制活性至关重要并与半胱天冬酶相互作用，而 RING 指结构域有时会增强抗细胞凋亡活性但不会单独抑制细胞凋亡。编码蛋白水平升高可能与癌症进展有关，并在化疗敏感性中发挥作用。可变剪接导致多个转录变体[RefSeq 提供，2013 年 7 月]

This gene encodes a member of the inhibitor of Apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit Apoptosis alone. Elevated levels of the encoded protein may be associated with Cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]

BIRC7 基因产物(2)

mRNA	Protein	Name
NM_022161.4	NP_071444.1	baculoviral IAP repeat-containing protein 7 isoform beta
NM_139317.3	NP_647478.1	baculoviral IAP repeat-containing protein 7 isoform alpha

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11024045	GOA
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	16729033	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	16729033	GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: 通过直接分析推断	11865055	GOA
involved in positive regulation of JNK cascade	IDA IDA: 通过直接分析推断	11865055	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	16729033	GOA
acts upstream of negative effect regulation of apoptotic process	IDA IDA: 通过直接分析推断	11865055	GOA
involved in regulation of cell population proliferation	IDA IDA: 通过直接分析推断	21617971	GOA
involved in regulation of natural killer cell apoptotic process	IDA IDA: 通过直接分析推断	18034418	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	17294084	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	17294084	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17294084	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BIRC7 蛋白结构

BIR

zf-C3HC4_3

0
100
200
298 a.a.

蛋白主名

其他名称

baculoviral IAP repeat-containing protein 7

RING finger protein 50

BIRC7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BIRC7	Q96CA5	BOLA1	Homo sapiens	Q9Y3E2	Validated Y2H	32296183
种属内	BIRC7	Q96CA5	POLR1C	Homo sapiens	O15160	Y2H Prey Pooling	25416956
种属内	BIRC7	Q96CA5	POLR1C	Homo sapiens	O15160	Validated Y2H	25416956
种属内	BIRC7	Q96CA5	LCOR	Homo sapiens	Q96JN0-2	Validated Y2H	32296183
种属内	BIRC7	Q96CA5	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
种属内	BIRC7	Q96CA5	DDX6	Homo sapiens	P26196	Y2H Array	25416956
种属内	BIRC7	Q96CA5	AURKC	Homo sapiens	Q9UQB9	Validated Y2H	32296183
种属内	BIRC7	Q96CA5	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
种属内	BIRC7	Q96CA5	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
种属内	BIRC7	Q96CA5	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
种属内	BIRC7	Q96CA5	BIRC2	Homo sapiens	Q13490	Anti Tag CoIP	33961781
种属内	BIRC7	Q96CA5	BIRC2	Homo sapiens	Q13490	Anti Tag CoIP	28514442
种属内	BIRC7	Q96CA5	BIRC2	Homo sapiens	Q13490	Y2H Array	31515488
种属内	BIRC7	Q96CA5	BIRC2	Homo sapiens	Q13490	Y2H Prey Pooling	25416956
种属内	BIRC7	Q96CA5	BIRC2	Homo sapiens	Q13490	Validated Y2H	25416956
种属内	BIRC7	Q96CA5	CASP9	Homo sapiens	P55211	Y2H Prey Pooling	25416956
种属内	BIRC7	Q96CA5	CASP9	Homo sapiens	P55211	Anti Tag CoIP	11801603
种属内	BIRC7	Q96CA5	CASP9	Homo sapiens	P55211	CoIP	11024045
种属内	BIRC7	Q96CA5	CASP9	Homo sapiens	P55211	Pull Down	11801603
种属内	BIRC7	Q96CA5	HTRA2	Homo sapiens	O43464	Anti Tag CoIP	33961781
种属内	BIRC7	Q96CA5	HTRA2	Homo sapiens	O43464	FPS	11801603
种属内	BIRC7	Q96CA5	HTRA2	Homo sapiens	O43464	Pull Down	11801603
种属内	BIRC7	Q96CA5	DIABLO	Homo sapiens	Q9NR28	Pull Down	11801603
种属内	BIRC7	Q96CA5	DIABLO	Homo sapiens	Q9NR28	Anti Tag CoIP	11801603
种属内	BIRC7	Q96CA5	DIABLO	Homo sapiens	Q9NR28	Anti Tag CoIP	33961781
种属内	BIRC7	Q96CA5	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
种属内	BIRC7	Q96CA5	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
种属内	BIRC7	Q96CA5	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
种属内	BIRC7	Q96CA5	FAM124B	Homo sapiens	Q9H5Z6	Y2H Prey Pooling	25416956
种属内	BIRC7	Q96CA5	FAM124B	Homo sapiens	Q9H5Z6	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 BIRC7 蛋白

目录号	产品名	蛋白编号	纯度
HY-P77065	Livin/BIRC7 Protein, Human (His)	Q96CA5-1 (M1-S298)	≥95%

关联疾病

疾病名称

别名

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-50685	A 410099.1		99.30%	否
HY-RS01515	BIRC7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	BIRC7	VGNC	VGNC:60119
Mus musculus	BIRC7	MGD	MGI:2676458
Macaca mulatta	BIRC7	VGNC	VGNC:70302
Canis familiaris	BIRC7	VGNC	VGNC:38463
Bos taurus	BIRC7	VGNC	VGNC:26503
Rattus norvegicus	BIRC7	RGD	RGD:1562883
Others	BIRC7	NCBI

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