Dnajb1 - DnaJ heat shock protein family (Hsp40) member B1 Gene

中文名称：DnaJ 热休克蛋白家族 (Hsp40) 成员 B1

种属: Mus musculus

同用名: DjB1; Hdj1; HSPF1; Hsp40; 0610007I11Rik

关于 Dnajb1

功能概要

该基因编码 DnaJ 或 Hsp40（热休克蛋白 40 kD）蛋白质家族的成员。编码的蛋白质是一种分子伴侣，可刺激 HSP70 热休克蛋白的 ATP 酶活性，以促进蛋白质折叠并防止错误折叠的蛋白质聚集。所编码的蛋白质还可以抑制细胞凋亡。来自该基因纯合基因敲除小鼠的腹膜巨噬细胞表现出耐热性受损。可变剪接导致多个转录本变体。 [RefSeq 提供，2015 年 4 月]

This gene encodes a member of the DnaJ or HSP40 (heat shock protein 40 kD) family of proteins. The encoded protein is a molecular chaperone that stimulates the ATPase activity of HSP70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. The encoded protein may also inhibit Apoptosis. Peritoneal macrophages derived from homozygous knockout mice for this gene exhibit impaired heat tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]