Tlr9 - toll-like receptor 9 Gene

中文名称：Toll 样受体 9

种属: Mus musculus

关于 Tlr9

功能概要

预测该基因编码的蛋白可启动 interleukin-1 受体结合活性；模式识别受体活动；和 siRNA 结合活性。参与多个过程，包括细胞因子产生的正调节；防御反应的调节；大分子生物合成过程的调控。作用于多个过程的上游或内部，包括细胞对氯喹的反应； ERK1 和 ERK2 级联的负调控；和调节树突状细胞细胞因子的产生。位于细胞质囊泡中；内质网；和质膜。在肠和小肠粘膜中表达。该基因的人类直系同源物与多种疾病有关，包括过敏性支气管肺曲霉病；囊性纤维化;肾小球肾炎（多发性）；乙型肝炎；和肺部疾病（多种）。与人类 TLR9（toll 样受体 9）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable interleukin-1 receptor binding activity; pattern recognition receptor activity; and siRNA binding activity. Involved in several processes, including positive regulation of cytokine production; regulation of defense response; and regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including cellular response to chloroquine; negative regulation of ERK1 and ERK2 cascade; and regulation of dendritic cell cytokine production. Located in cytoplasmic vesicle; endoplasmic reticulum; and plasma membrane. Is expressed in intestine and small intestine mucosa. Human ortholog(s) of this gene implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); hepatitis B; and lung disease (multiple). Orthologous to human TLR9 (toll like receptor 9). [provided by Alliance of Genome Resources, Apr 2022]