2. Immunology/Inflammation Anti-infection
  3. Toll-like Receptor (TLR) Bacterial
  4. ODN 1668 sodium

ODN 1668 sodium 

目录号: HY-150726C 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

ODN 1668 sodium 是 B 类 CpG ODN (寡脱氧核苷酸)，是一种 TLR-9 激动剂。ODN 1668 sodium 具有强免疫调节性，可提升抗体 IgG2 亚型水平，促进 T 细胞和 B 细胞的免疫反应，可用于疫苗佐剂的研究。此外，CpG ODN 1668 sodium 在座头石斑鱼中通过 CaTLR9 依赖途径诱导抗菌免疫反应。序列：5’-tccatgacgttcctgatgct-3’。

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DNA, d(P-thio)(T-C-C-A-T-G-A-C-G-T-T-C-C-T-G-A-T-G-C-T), sodium salt

ODN 1668 sodium Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥1730
In-stock
5 mg ￥3980
In-stock
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Customer Review

Other Forms of ODN 1668 sodium:

ODN 1668 sodium 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ODN 1668 sodium, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 sodium has strong immune regulatory properties, can enhance the level of antibody IgG2 subtype, promote the immune response of T cells and B cells, and can be used in the study of vaccine adjuvants. In addition, CpG ODN 1668 sodium induces an antimicrobial immune response via a CaTLR9 dependent pathway in groupers. Sequence: 5'-tccatgacgttcctgatgct-3’[1][2][3][4].

IC50 & Target[4]

TLR9

 

体外研究
(In Vitro)

非盐剂量：
ODN 1668 (6-60 µg/mL；12-72 小时) 在小鼠骨髓来源巨噬细胞中可增加 S100A8/A9、IL-6 和 β-半乳糖苷酶的合成[1]。
ODN 1668 (24 小时) 促进 B 细胞活化和增殖，增加 CD86 和 CD25 表达[2]。
ODN 1668 (0.3-3.0 μM；4 天) 在抗 CD3 处理的 CD8+ T 细胞中，以剂量依赖的方式促进细胞生长[2]。
ODN 1668 (0.25-32 μg/mL；12 小时) 能促进头肾淋巴细胞的增殖，增强免疫基因的表达[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ODN 1668 sodium 相关抗体:

Real Time qPCR[3]

Cell Line: Head kidney lymphocytes
Concentration: 2 μg/mL
Incubation Time: 12 h
Result: Increased the mRNA levels of TLR9, IL-1β, IL-6, IL-8, TNF-α, IFN-γ, MHC-Iα and MHC-IIα.
体内研究
(In Vivo)

非盐剂量：
ODN 1668 (10 nmol ≈ 63.6 μg；后脚垫内注射；单剂量) 在 OVA 处理的小鼠中显著增强了抗体反应，增加了 IgG2a 和 IgG2b 的滴度[2]。
ODN 1668 (15 μg；肌肉注射；单剂量) 提高了座头石斑鱼对迟达绦虫感染的抗菌免疫力，在肝脏、脾脏和肾脏的抑菌活性最显著[3]。
ODN 1668 (1-5 mg/kg；腹腔/皮下注射；单剂量) 可引起大鼠发烧、厌食和脑部炎症[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (175-200 g)[4]
Dosage: 1 and 5 mg/kg
Administration: Intraperitoneal and subcutaneous injection, single dose
Result: Caused moderate fever and anorexia.
Induced a significant increase of IL-6.
Increased expression of inflammatory genes in the hypothalamus (SOCS3, PGE2, COX-2 and mPGES).
Activated inflammatory transcription factors in the rat brain (STAT3 and NF-IL6).
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥99.0%

COA (184 KB) LCMS (102 KB)

产品使用指南 (1538 KB)
参考文献

ODN 1668 sodium 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ODN 1668ODN1668ODN-1668Toll-like Receptor (TLR)Bacterialimmunostimulatory sequencevaccine adjuvantB cellsT cellsmacrophageshead kidney lymphocytesInhibitorinhibitorinhibit

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目录号：
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