CASP4 - caspase 4 Gene

中文名称：半胱天冬酶 4

种属: Homo sapiens

同用名: TX; Mih1; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II

基因 ID: 837 | 基因类型: protein coding

关于 CASP4

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:104,942,866-104,968,574 (from NCBI)

This gene has 13 transcripts (splice variants), 421 orthologues and 16 paralogues. Ubiquitous expression in appendix (RPKM 42.7), lymph node (RPKM 37.1) and 24 other tissues.

功能概要

该基因编码的蛋白质是半胱氨酸-天冬氨酸蛋白酶 (半胱天冬酶) 家族的成员。半胱天冬酶的顺序激活在细胞凋亡的执行阶段起着核心作用。半胱天冬酶作为无活性的酶原存在，由前结构域和大小蛋白酶亚基组成。半胱天冬酶的激活需要对保守的内部天冬氨酸残基进行蛋白水解处理，以生成由大亚基和小亚基组成的异二聚体酶。这种半胱天冬酶能够切割并激活其自身的前体蛋白以及半胱天冬酶 1 前体。当过表达时，该基因会诱导细胞凋亡。可变剪接导致编码不同亚型的转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (Caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell Apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric Enzyme consisting of the large and small subunits. This Caspase is able to cleave and activate its own precursor protein, as well as Caspase 1 precursor. When overexpressed, this gene induces cell Apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

CASP4 基因产物(4)

mRNA	Protein	Name
XM_011543019.2	XP_011541321.1	caspase-4 isoform X1
NM_001225.4	NP_001216.1	caspase-4 isoform alpha precursor
NM_033306.3	NP_150649.1	caspase-4 isoform gamma precursor
NM_033307.2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables CARD domain binding	IPI IPI: 通过物理相互作用推断	16920334	GOA
enables cysteine-type endopeptidase activity	IDA IDA: 通过直接分析推断	16920334	GOA
enables lipid binding	IDA IDA: 通过直接分析推断	25119034	GOA
enables lipopolysaccharide binding	IDA IDA: 通过直接分析推断	25119034	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	29077095	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to amyloid-beta	IMP IMP: 通过突变表型推断	15123740	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: 通过直接分析推断	33377178	GOA
involved in defense response to bacterium	IDA IDA: 通过直接分析推断	25119034	GOA
involved in intrinsic apoptotic signaling pathway	IMP IMP: 通过突变表型推断	15123740	GOA
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	15123740	GOA
involved in non-canonical inflammasome complex assembly	IDA IDA: 通过直接分析推断	25119034	GOA
involved in positive regulation of inflammatory response	IDA IDA: 通过直接分析推断	33377178	GOA
involved in positive regulation of interleukin-18-mediated signaling pathway	IDA IDA: 通过直接分析推断	33377178	GOA
involved in positive regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: 通过直接分析推断	16920334	GOA
involved in protein autoprocessing	IDA IDA: 通过直接分析推断	32109412	GOA
involved in protein maturation	IDA IDA: 通过直接分析推断	25119034	GOA
involved in pyroptotic inflammatory response	IDA IDA: 通过直接分析推断	31268602	GOA
involved in regulation of inflammatory response	IDA IDA: 通过直接分析推断	32109412	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cytosol	IDA IDA: 通过直接分析推断	23661706	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	15123740	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	15123740	GOA
part of non-canonical inflammasome complex	IDA IDA: 通过直接分析推断	25119034	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	16920334	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CASP4 蛋白结构

CARD

Peptidase_C14

0
100
200
300
377 a.a.

蛋白主名

其他名称

caspase-4

CASP-4	ICE and Ced-3 homolog 2
ICE(rel)-II	apoptotic cysteine protease Mih1/TX
caspase 4, apoptosis-related cysteine peptidase	caspase 4, apoptosis-related cysteine protease
protease ICH-2	protease TX

CASP4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CASP4	P49662	ARHGAP44	Homo sapiens	Q17R89	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cowpox

Yaba

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Cystinosis

Cystine Storage Disease	Cystine Diathesis
Cystine Disease	Cystinoses
Protein Defect Of Cystin Transport	Cystin Transport, Protein Defect Of
Nephropathic Cystinosis	Protein Defect Of Cystine Transport

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01955	CASP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01956	Casp4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01957	Casp4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CASP4	MGD	MGI:107700
Macaca mulatta	CASP4	VGNC	VGNC:70543
Rattus norvegicus	CASP4	RGD	RGD:621757

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CASP4 - caspase 4 Gene

关于 CASP4

功能概要

CASP4 基因产物(4)

CASP4 蛋白结构

CASP4 蛋白互作信息

关联疾病

直系同源

热门区域

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CASP4 - caspase 4 Gene

关于 CASP4

功能概要

CASP4 基因产物(4)

CASP4 蛋白结构

CASP4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z