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  2. CASP4 - caspase 4 Gene

CASP4 - caspase 4 Gene

中文名称:半胱天冬酶 4

种属: Homo sapiens

同用名: TX; Mih1; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II

基因 ID: 837 | 基因类型: protein coding

关于 CASP4

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:104,942,866-104,968,574 (from NCBI)

This gene has 13 transcripts (splice variants), 421 orthologues and 16 paralogues. Ubiquitous expression in appendix (RPKM 42.7), lymph node (RPKM 37.1) and 24 other tissues.

功能概要

该基因编码的蛋白质是半胱氨酸-天冬氨酸蛋白酶 (半胱天冬酶) 家族的成员。半胱天冬酶的顺序激活在细胞凋亡的执行阶段起着核心作用。半胱天冬酶作为无活性的酶原存在,由前结构域和大小蛋白酶亚基组成。半胱天冬酶的激活需要对保守的内部天冬氨酸残基进行蛋白水解处理,以生成由大亚基和小亚基组成的异二聚体酶。这种半胱天冬酶能够切割并激活其自身的前体蛋白以及半胱天冬酶 1 前体。当过表达时,该基因会诱导细胞凋亡。可变剪接导致编码不同亚型的转录变体。[RefSeq 提供,2008 年 7 月]

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (Caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell Apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric Enzyme consisting of the large and small subunits. This Caspase is able to cleave and activate its own precursor protein, as well as Caspase 1 precursor. When overexpressed, this gene induces cell Apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

CASP4 基因产物(4)

mRNA Protein Name
XM_011543019.2 XP_011541321.1 caspase-4 isoform X1
NM_001225.4 NP_001216.1 caspase-4 isoform alpha precursor
NM_033306.3 NP_150649.1 caspase-4 isoform gamma precursor
NM_033307.2

CASP4 蛋白结构

CARD

CARD: Caspase recruitment domain (5 - 83)

Peptidase_C14

Peptidase_C14: Caspase domain (136 - 372)

  • 0
  • 100
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  • 300
  • 377 a.a.
蛋白主名 其他名称

caspase-4

CASP-4

ICE and Ced-3 homolog 2

ICE(rel)-II

apoptotic cysteine protease Mih1/TX

caspase 4, apoptosis-related cysteine peptidase

caspase 4, apoptosis-related cysteine protease

protease ICH-2

protease TX

关联疾病

疾病名称 别名
Cowpox

Yaba

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Cystinosis

Cystine Storage Disease

Cystine Diathesis

Cystine Disease

Cystinoses

Protein Defect Of Cystin Transport

Cystin Transport, Protein Defect Of

Nephropathic Cystinosis

Protein Defect Of Cystine Transport

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CASP4 MGD MGI:107700
Macaca mulatta CASP4 VGNC VGNC:70543
Rattus norvegicus CASP4 RGD RGD:621757