2. Gene
  3. HMGN3 - high mobility group nucleosomal binding domain 3 Gene

HMGN3 - high mobility group nucleosomal binding domain 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：高迁移率基团核小体结合域 3

种属: Homo sapiens

同用名: TRIP7; PNAS-24; PNAS-25

基因 ID: 9324 | 基因类型: protein coding

关于 HMGN3

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:79,201,245-79,234,682 (from NCBI)

This gene has 4 transcripts (splice variants), 118 orthologues and 3 paralogues. Ubiquitous expression in heart (RPKM 45.8), adrenal (RPKM 40.5) and 25 other tissues.

功能概要

由该基因编码的蛋白质在甲状腺激素存在的情况下与甲状腺激素受体 β 结合。编码的蛋白质是 HMGN 蛋白质家族的一员，被认为可以降低核小体中染色质纤维的紧密度，从而增强染色质模板的转录。已发现该基因编码不同亚型的可变剪接转录物变体。 1 号染色体上有一个相关的假基因。[RefSeq 提供，2016 年 1 月]

The protein encoded by this gene binds Thyroid Hormone Receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016]

HMGN3 基因产物(9)

mRNA Protein Name
NM_001201362.2 NP_001188291.1 high mobility group nucleosome-binding domain-containing protein 3 isoform c
NM_001201363.2 NP_001188292.1 high mobility group nucleosome-binding domain-containing protein 3 isoform d
NM_001318884.2 NP_001305813.1 high mobility group nucleosome-binding domain-containing protein 3 isoform e
NM_001318885.2 NP_001305814.1 high mobility group nucleosome-binding domain-containing protein 3 isoform f
NM_001318886.2 NP_001305815.1 high mobility group nucleosome-binding domain-containing protein 3 isoform g
NM_001318887.2 NP_001305816.1 high mobility group nucleosome-binding domain-containing protein 3 isoform h
NM_001318888.2 NP_001305817.1 high mobility group nucleosome-binding domain-containing protein 3 isoform i
NM_004242.4 NP_004233.1 high mobility group nucleosome-binding domain-containing protein 3 isoform a
NM_138730.3 NP_620058.1 high mobility group nucleosome-binding domain-containing protein 3 isoform b
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
33468658 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HMGN3 蛋白结构

HMG14_17

HMG14_17: HMG14 and HMG17 (2 - 96)

  • 0
  • 99 a.a.
蛋白主名 其他名称

high mobility group nucleosome-binding domain-containing protein 3

TR-interacting protein 7

重组 HMGN3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75810 HMGN3 Protein, Human (His) Q15651-2 (M1-N77) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06245 HMGN3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HMGN3 RGD RGD:1359106
Bos taurus HMGN3 VGNC VGNC:49985
Mus musculus HMGN3 MGD MGI:2138069
Canis familiaris HMGN3 VGNC VGNC:57223
Macaca mulatta HMGN3 VGNC VGNC:73385
Others HMGN3 NCBI
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