Mgat2 - alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Gene

中文名称：α-1 ,6-甘露糖糖蛋白 2-β-N-乙酰氨基葡萄糖转移酶

种属: Rattus norvegicus

同用名: Gnt2

关于 Mgat2

功能概要

该基因编码的蛋白可启动 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase 活性和碳水化合物结合活性。参与蛋白质 N-连接的糖基化。预测位于高尔基体和粗面内质网膜的细胞质侧。预计是大核糖体亚基的一部分。预测在高尔基体膜中有活性。该基因的人类直系同源物与 IIa 型糖基化先天性疾病有关。与人 MGAT2（α-1,6-甘露糖基糖蛋白 2-β-N-乙酰氨基葡萄糖转移酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity and carbohydrate binding activity. Involved in protein N-linked glycosylation. Predicted to be located in Golgi apparatus and cytoplasmic side of rough endoplasmic reticulum membrane. Predicted to be part of large ribosomal subunit. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIa. Orthologous to human MGAT2 (alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]