1. Metabolic Enzyme/Protease
  2. Acyltransferase
  3. S-309309

S-309309 是一种具有口服活性、选择性的 MGAT2 抑制剂。S-309309 能用于代谢的相关研究。

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S-309309 Chemical Structure

S-309309 Chemical Structure

CAS No. : 2267352-04-3

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查看 Acyltransferase 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

S-309309 is an orally active and selective MGAT2 inhibitor. S-309309 can be used in metabolism-related research[1].

IC50 & Target

MGAT2

 

体内研究
(In Vivo)

S-309309 (3 mg/kg, 口服, 每天两次, 6-13 周) 抑制了DIO小鼠的食物摄入和体重增加[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High fat diet (HFD)-induced obesity (DIO) mice[1]
Dosage: 3 mg/kg
Administration: p.o., b.i.d., 6-13 weeks
Result: Decreased in insulin resistance index, hepatic triglycerides content, plasma alanine aminotransferase and aspartate aminotransferase level, and gene expression related to fibrosis.
Enhanced energy expenditure and upregulation of intestinal gene expression related to long-chain fatty acid beta oxidation.
分子量

517.51

Formula

C23H21F2N5O5S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
S-309309
目录号:
HY-159422
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