2. Gene
  3. HS3ST4 - heparan sulfate-glucosamine 3-sulfotransferase 4 Gene

HS3ST4 - heparan sulfate-glucosamine 3-sulfotransferase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：硫酸乙酰肝素-氨基葡萄糖 3-磺基转移酶 4

种属: Homo sapiens

同用名: 30ST4; 3OST4; 3-OST-4; h3-OST-4

基因 ID: 9951 | 基因类型: protein coding

关于 HS3ST4

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:25,691,959-26,137,685 (from NCBI)

This gene has 2 transcripts (splice variants), 195 orthologues and 10 paralogues. Biased expression in brain (RPKM 7.8), spleen (RPKM 1.0) and 1 other tissue.

功能概要

该基因编码硫酸乙酰肝素 D-葡糖胺基 3-O-磺基转移酶 4。该酶在硫酸乙酰肝素中产生 3-O-硫酸化葡糖胺基残基。细胞表面硫酸乙酰肝素被单纯疱疹病毒 1 型 (HSV-1) 用作受体，该基因的表达被认为在 HSV-1 发病机制中发挥作用。[RefSeq 提供，2008 年 7 月]

This gene encodes the Enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This Enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis. [provided by RefSeq, Jul 2008]

HS3ST4 基因产物(1)

mRNA Protein Name
NM_006040.3 NP_006031.2 heparan sulfate glucosamine 3-O-sulfotransferase 4

HS3ST4 蛋白结构

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (198 - 433)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 456 a.a.
蛋白主名 其他名称

heparan sulfate glucosamine 3-O-sulfotransferase 4

heparan sulfate (glucosamine) 3-O-sulfotransferase 4

关联疾病

疾病名称 别名
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Herpes Zoster

Shingles

Zoster

Herpes Zona

Herpes Zoster Disease

Zona Zoster

Herpes Zoster Of Skin And Mucous Membranes

Zoster Nos

Zoster With Nervous System Involvement
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-E70172 Heparan Sulfate 3-O-Sulfotransferase 4 Modulator / 否
HY-RS06380 HS3ST4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta HS3ST4 VGNC VGNC:104731
Rattus norvegicus HS3ST4 RGD RGD:11422907
Felis catus HS3ST4 VGNC VGNC:80581
Mus musculus HS3ST4 MGD MGI:1333792
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