2. Protein Tyrosine Kinase/RTK
  3. PDGFR
  4. Gint4.T aptamer sodium

Gint4.T aptamer sodium 是基于抗核酸酶 RNA 适体、靶向血小板衍生生长因子受体 β (PDGFRβ) 的拮抗剂 (Kd: 9.6 nM)。Gint4.T aptamer sodium 抑制 PDGFRβ 异二聚化和 EGFR 反式激活。在体内可显着抑制细胞迁移和增殖、诱导分化并阻止肿瘤生长。Gint4.T aptamer sodium 可特异性抑制 PDGFRβ 介导的间充质干细胞 (MSC) 对肿瘤微环境的趋向性。

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DNA, 5'-UGUCGUGGGGCAUCGAGUAAAUGCAAUUCGACA-3', sodium salt

Gint4.T aptamer sodium Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Gint4.T aptamer sodium 相关抗体

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PDGFR PDGFRβ PDGFRα

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment[1].

IC50 & Target

PDGFRβ[1]
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Gint4.T aptamer sodium 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gint4.T aptamerPDGFRPlatelet-derived growth factor receptorAnti-nucleaseRNA aptamerplatelet-derived growth factor receptor betamesenchymal stem cellstumor microenvironmentInhibitorinhibitorinhibit

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产品名称：
Gint4.T aptamer sodium
目录号：
HY-160053
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