2. Academic Validation
  3. Agonodepsides a and B: two new depsides from a filamentous fungus F7524

Agonodepsides a and B: two new depsides from a filamentous fungus F7524

  • J Nat Prod. 2002 Jul;65(7):1037-8. doi: 10.1021/np010626i.
Shugeng Cao 1,  Alex S Y Lee,  Yicun Huang,  Horst Flotow,  Siewbee Ng,  Mark S Butler,  Antony D Buss
Affiliations

Affiliation

  • 1 Centre for Natural Product Research, Institute of Molecular and Cell Biology, 59A Science Park Drive, The Fleming, Singapore Science Park 118240, Singapore. shugeng@merlionpharm.com
PMID: 12141869 DOI: 10.1021/np010626i
Abstract

Two new compounds, agonodepsides A (1) and B (2), were isolated from a nonsporulating filamentous fungus, F7524. The compounds were purified via reversed-phase chromatography and their structures determined by spectroscopic methods. Agonodepside A (1) was found to inhibit the mycobacterial InhA Enzyme with an IC50 value of 75 microM, while 2 was inactive at 100 microM.

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