2. Academic Validation
  3. Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)--Hit to Lead studies

Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)--Hit to Lead studies

  • Bioorg Med Chem Lett. 2009 Sep 1;19(17):5063-6. doi: 10.1016/j.bmcl.2009.07.040.
Honghe Wan 1,  Tram Huynh,  Suhong Pang,  Jieping Geng,  Wayne Vaccaro,  Michael A Poss,  George L Trainor,  Matthew V Lorenzi,  Marco Gottardis,  Lata Jayaraman,  Ashok V Purandare
Affiliations

Affiliation

  • 1 Bristol-Myers Squibb Pharmaceutical Research and Development, Princeton, NJ 08543, USA. Honghe.wan@bms.com
PMID: 19632837 DOI: 10.1016/j.bmcl.2009.07.040
Abstract

Hit to Lead optimization and SAR development led to the identification of the potent and selective benzo[d]imidazole inhibitor (17b) of Co-activator Associated Arginine Methyltransferase (CARM1).

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