2. Academic Validation
  3. Effect of alpha-resorcylic acid-L-phenylalanine amide on collagen synthesis and matrix metalloproteinase expression in fibroblasts

Effect of alpha-resorcylic acid-L-phenylalanine amide on collagen synthesis and matrix metalloproteinase expression in fibroblasts

  • Bioorg Med Chem Lett. 2014 Feb 1;24(3):742-5. doi: 10.1016/j.bmcl.2013.12.110.
Seon-Yeong Kwak 1,  Jin-Mi Noh 2,  Suyeon Lee 3,  So Hun Lee 3,  Su-ji Jeon 1,  Hye-In Kim 1,  Jong-Ho Kim 4,  Yoon-Sik Lee 5
Affiliations

Affiliations

  • 1 Department of Chemical Engineering, Hanyang University, Ansan 426-791, Republic of Korea.
  • 2 School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea.
  • 3 R&D Center, Bioland Ltd., Byeongcheon, Dongnam, Cheonan, Chungnam 330-863, Republic of Korea.
  • 4 Department of Chemical Engineering, Hanyang University, Ansan 426-791, Republic of Korea. Electronic address: kjh75@hanyang.ac.kr.
  • 5 School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea. Electronic address: yslee@snu.ac.kr.
PMID: 24411126 DOI: 10.1016/j.bmcl.2013.12.110
Abstract

Regulation of collagen synthesis and Matrix Metalloproteinases (MMPs) expression levels has been an important issue in medicinal, pharmaceutical and cosmetic industries. Herein, α-Resorcylic acid-phenylalanine amide (α-RA-F) was prepared and its biological activities were observed. We found that α-RA-F boosted collagen synthesis and reduced MMPs expression levels in human fibroblasts without cytotoxicity.

Keywords

Collagen synthesis; Resorcylic acid derivative; Suppression of MMPs expression.

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