2. Academic Validation
  3. The effects of single L-amino acid substitutions on the lethal potencies of the microcystins

The effects of single L-amino acid substitutions on the lethal potencies of the microcystins

  • Toxicon. 1989;27(7):825-8. doi: 10.1016/0041-0101(89)90051-2.
R D Stoner 1,  W H Adams,  D N Slatkin,  H W Siegelman
Affiliations

Affiliation

  • 1 Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973.
PMID: 2506678 DOI: 10.1016/0041-0101(89)90051-2
Abstract

Microcystin-LR and -LA are more toxic than microcystin-LY and -RR in adult mice. They induce different degrees of thrombocytopenia and leukopenia, and the lethalities of their binary and ternary mixtures are addictive. Postnatal mice are resistant to doses of microcystin-LR that are lethal to adults but they are susceptible to higher doses. Substitution of a single L-amino acid for another in a microcystin markedly affects the dosimetric potency, but not the pathophysiology of its toxicity.

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