2. Academic Validation
  3. Loganin protects against pancreatitis by inhibiting NF-κB activation

Loganin protects against pancreatitis by inhibiting NF-κB activation

  • Eur J Pharmacol. 2015 Oct 15;765:541-50. doi: 10.1016/j.ejphar.2015.09.019.
Myoung-Jin Kim 1,  Gi-Sang Bae 2,  Il-Joo Jo 2,  Sun-Bok Choi 1,  Dong-Goo Kim 1,  Joon-Yeon Shin 2,  Sung-Kon Lee 1,  Min-Jun Kim 1,  Soyoung Shin 3,  Ho-Joon Song 1,  Sung-Joo Park 4
Affiliations

Affiliations

  • 1 Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, South Korea; BK21 Plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, South Korea.
  • 2 Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, South Korea; Hanbang Body-fluid Research Center, Wonkwang University, Iksan, Jeonbuk, South Korea.
  • 3 Department of Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, South Korea.
  • 4 Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, South Korea; BK21 Plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, South Korea; Hanbang Body-fluid Research Center, Wonkwang University, Iksan, Jeonbuk, South Korea. Electronic address: parksj08@wku.ac.kr.
PMID: 26407655 DOI: 10.1016/j.ejphar.2015.09.019
Abstract

Acute pancreatitis (AP) is an inflammatory disease of the pancreas, which, in its most severe form, is associated with multi-organ failure and death. Loganin, a major iridoid glycoside obtained from Corni fructus, has been shown to have anti-inflammatory and anti-shock effects. However, the effects of loganin on AP have not been determined. Pre-treatment of loganin reduced pancreatic damage and AP-associated lung injury and attenuated the severity of AP, as evidenced by (1) a reduction in several biochemical parameters (pancreatic weight to body weight ratio, myeloperoxidase activity, and level of amylase) and (2) production of pro-inflammatory cytokines such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α. However, post-treatment of loganin failed to improve pancreatic damage and biochemical parameters of AP, but could inhibit the AP-induced elevation of IL-1β and TNF-α significantly. In addition, cerulein-induced activation of nuclear factor (NF)-κB was inhibited in the pancreas by administration of loganin. In conclusion, these results suggest that loganin exhibits an anti-inflammatory effect in cases of AP and its pulmonary complications through inhibition of NF-κB activation.

Keywords

Acute pancreatitis; Loganin; Nuclear factor-κB; Proinflammatory cytokines.

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