2. Academic Validation
  3. Two new secoiridoids and other anti-hepatitis B virus active constituents from Swertia patens

Two new secoiridoids and other anti-hepatitis B virus active constituents from Swertia patens

  • J Asian Nat Prod Res. 2016 Jun;18(6):528-34. doi: 10.1080/10286020.2015.1116523.
Kang He 1,  Chang-An Geng 1,  Tuan-Wu Cao 1,  Hong-Ling Wang 1,  Yun-Bao Ma 1,  Xue-Mei Zhang 1,  Ji-Jun Chen 1
Affiliations

Affiliation

  • 1 a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
PMID: 26727588 DOI: 10.1080/10286020.2015.1116523
Abstract

Two new secoiridoids, swerpatic acid (1) with an unusual C8 skeleton and swerpalactone (2), were isolated along with ten known compounds (3-12) from the whole Plants of Swertia patens. Their structures were elucidated by comprehensive spectroscopic analyses. Eight compounds were evaluated for their anti-hepatitis B virus (HBV) activities on Hep G 2.2.15 cell line in vitro. Compounds 4 and 10 showed moderate inhibitory activities on the secretion of HBsAg with IC50 values of 1.96 and 0.50 mM.

Keywords

Swertia patens; anti-HBV activity; secoiridoids; swerpalactone; swerpatic acid.

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