2. Academic Validation
  3. Macrolides from a Marine-Derived Fungus, Penicillium meleagrinum var. viridiflavum, Showing Synergistic Effects with Fluconazole against Azole-Resistant Candida albicans

Macrolides from a Marine-Derived Fungus, Penicillium meleagrinum var. viridiflavum, Showing Synergistic Effects with Fluconazole against Azole-Resistant Candida albicans

  • J Nat Prod. 2016 Apr 22;79(4):1208-12. doi: 10.1021/acs.jnatprod.6b00019.
Miki Okabe 1,  Takashi Sugita 1,  Kaoru Kinoshita 1,  Kiyotaka Koyama 1
Affiliations

Affiliation

  • 1 Department of Pharmacognosy and Phytochemistry and ‡Department of Microbiology, Meiji Pharmaceutical University , 2-522-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan.
PMID: 27014845 DOI: 10.1021/acs.jnatprod.6b00019
Abstract

Two new 13-membered macrolides (1, 7), along with known 13-membered macrolides PF1163A, B, D, H, and F (2-6), were isolated from a strain of a marine-derived fungus, Penicillium meleagrinum var. viridiflavum. The structures of 1 and 7 were elucidated from spectroscopic data (NMR, MS, IR). Compounds 1-7 showed synergistic effects with fluconazole against azole-resistant Candida albicans by a checkerboard assay.

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  • HY-123457
    抗真菌剂/C-4 sterol methyl oxidase抑制剂
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