2. Academic Validation
  3. Protostane-Type Triterpenoids from Alisma orientale

Protostane-Type Triterpenoids from Alisma orientale

  • Chem Biodivers. 2017 Dec;14(12). doi: 10.1002/cbdv.201700452.
Hong-Mei Li 1 2,  Xue-Jiao Chen 1,  Dan Luo 1,  Min Fan 1,  Zhi-Jun Zhang 1,  Li-Yan Peng 1,  Xing-De Wu 1,  Rong-Tao Li 2,  Xu Ji 1,  Qin-Shi Zhao 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
  • 2 Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.
PMID: 29139211 DOI: 10.1002/cbdv.201700452
Abstract

Twenty-eight protostane triterpenoids, including a new degraded one (1), nine new ones (2 - 10), and two new natural ones (11 and 12), have been isolated from the dried rhizomes of Alisma orientale. Alisol R (1) was the first 20,21,22,23,24,25,26,27-octanorprotostane triterpenoid. The absolute configurations of 25-methoxyalisol F (2) and 16β-hydroperoxyalisol B 23-acetate (3) were determined by X-ray diffraction analysis. In addition, alismaketone-B 23-acetate (28) showed potent vasorelaxant activity on endothelium-intact thoracic aorta rings precontracted with KCl.

Keywords

Alisma orientale; Alismataceae; Alismatis Rhizoma; Protostane triterpenoids; Vasorelaxant activity.

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