2. Academic Validation
  3. Monocyclic and tricyclic analogs of quinolones: mechanism of action

Monocyclic and tricyclic analogs of quinolones: mechanism of action

  • Antimicrob Agents Chemother. 1987 Apr;31(4):614-6. doi: 10.1128/AAC.31.4.614.
N H Georgopapadakou,  B A Dix,  P Angehrn,  A Wick,  G L Olson
PMID: 3037999 DOI: 10.1128/AAC.31.4.614
Abstract

The mode of action of Ro 13-5478 and Ro 14-9578, monocyclic and tricyclic Quinolone analogs, respectively, was examined for Escherichia coli and Staphylococcus aureus. The compounds showed Antibacterial activity and effects on cell morphology, replicative DNA biosynthesis, and gyrase-catalyzed DNA supercoiling that were comparable to those shown by nalidixic acid and by oxolinic acid compounds. The results suggest that their site of action is DNA gyrase and that a bicyclic Quinolone nucleus is not essential for activity.

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