2. Academic Validation
  3. Demethylzeylasteral (T-96) inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways

Demethylzeylasteral (T-96) inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways

  • Naunyn Schmiedebergs Arch Pharmacol. 2019 May;392(5):593-603. doi: 10.1007/s00210-019-01614-5.
Liu Li 1,  Yi Ji 1,  Junting Fan 2,  Furong Li 3,  Yan Li 3,  Mianhua Wu 4 5,  Haibo Cheng 6 7,  Changliang Xu 8 9
Affiliations

Affiliations

  • 1 The First Clinical Medical College, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • 2 School of Pharmacy, Nanjing Medical University, Nanjing, 210023, China.
  • 3 Department of Nephrology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
  • 4 The First Clinical Medical College, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, 210023, China. wumianhuanjucm@163.com.
  • 5 The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China. wumianhuanjucm@163.com.
  • 6 The First Clinical Medical College, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, 210023, China. nzychb@hotmail.com.
  • 7 The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China. nzychb@hotmail.com.
  • 8 The First Clinical Medical College, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, 210023, China. cl.xu81@gmail.com.
  • 9 The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China. cl.xu81@gmail.com.
PMID: 30729271 DOI: 10.1007/s00210-019-01614-5
Abstract

Inflammation is one of the characteristic features during the development of human tumors. A pro-inflammatory cytokine that is known to promote inflammation during Cancer development is the transforming growth factor-β (TGF-β). On the Other hand, demethylzeylasteral (T-96) is a natural compound isolated from Tripterygium wilfordii Hook F, which has been reported to have various pharmacological properties including anti-inflammatory and immunosuppressive activities. We investigated the effects of T-96 on the highly metastatic breast Cancer cell line, MDA-MB-231. Cell migration was assessed by scratch-wound migration assay, and the molecular mechanisms underlying the effects of T-96 were examined by qPCR and Western blot analyses. We also investigated the suppression effects of T-96 on the pulmonary metastasis in the 4T1 mouse model. T-96 inhibited TGF-β-induced migration and epithelial-mesenchymal transition both in vitro and in vivo. These results demonstrate that T-96 inhibited invasion of MDA-MB-231 and 4T1 cells via suppressing the canonical and non-canonical TGF-β signaling pathways.

Keywords

Breast cancer; Invasion; T-96; TGF-β.

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