2. Academic Validation
  3. Tumor microenvironment complexity and therapeutic implications at a glance

Tumor microenvironment complexity and therapeutic implications at a glance

  • Cell Commun Signal. 2020 Apr 7;18(1):59. doi: 10.1186/s12964-020-0530-4.
Roghayyeh Baghban 1 2,  Leila Roshangar 3,  Rana Jahanban-Esfahlan 4,  Khaled Seidi 5 6,  Abbas Ebrahimi-Kalan 7,  Mehdi Jaymand 8,  Saeed Kolahian 9,  Tahereh Javaheri 10,  Peyman Zare 11 12
Affiliations

Affiliations

  • 1 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 2 Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 3 Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 4 Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Jahanbanr@tbzmed.ac.ir.
  • 5 Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 6 Student Research Committees, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 7 Department of Neurosciences and Cognitive, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 8 Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • 9 Department of Experimental and Clinical Pharmacology and Pharmacogenomics, University Hospital Tuebingen, Tuebingen, Germany.
  • 10 Health Informatics Lab, Metropolitan College, Boston University, Boston, USA. Zohreh.javaheri@gmail.com.
  • 11 Dioscuri Center of Chromatin Biology and Epigenomics, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland. p.zare@nencki.edu.pl.
  • 12 Faculty of Medicine, Cardinal Stefan Wyszyński University in Warsaw, 01-938, Warsaw, Poland. p.zare@nencki.edu.pl.
PMID: 32264958 DOI: 10.1186/s12964-020-0530-4
Abstract

The dynamic interactions of Cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity of Cancer cell, clonal evolution and to increase the multidrug resistance ending in Cancer cell progression and metastasis. The reciprocal cell-cell/ECM interaction and tumor cell hijacking of non-malignant cells force stromal cells to lose their function and acquire new phenotypes that promote development and invasion of tumor cells. Understanding the underlying cellular and molecular mechanisms governing these interactions can be used as a novel strategy to indirectly disrupt Cancer cell interplay and contribute to the development of efficient and safe therapeutic strategies to fight Cancer. Furthermore, the tumor-derived circulating Materials can also be used as Cancer diagnostic tools to precisely predict and monitor the outcome of therapy. This review evaluates such potentials in various advanced Cancer models, with a focus on 3D systems as well as lab-on-chip devices. Video abstract.

Keywords

Apoptotic bodies; Cancer cell interactions; Cancer models; Cancer therapy; Cell-free DNA; Circulating tumor cells; Exosome; Extracellular matrix; Horizontal transfer; Stroma cell; Tumor microenvironment.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z