2. Academic Validation
  3. Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD

Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD

  • Cells. 2020 Apr 29;9(5):1102. doi: 10.3390/cells9051102.
Sonali Nashine 1,  M Cristina Kenney 1 2
Affiliations

Affiliations

  • 1 Department of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USA.
  • 2 Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA 92697, USA.
PMID: 32365540 DOI: 10.3390/cells9051102
Abstract

Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial‑Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we summarize the varied effects of MDPs on cellular and mitochondrial health, which establish the merit of MDPs as therapeutic targets for AMD. We argue that further research to delve into the mechanisms of action and delivery of MDPs may advance the field of AMD therapy.

Keywords

Age-related Macular Degeneration (AMD); HNG; Humanin; MDPs; MOTS-c; RPE; SHLPs; mitochondria; mitochondrial-derived peptides; neuroprotection.

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