2. Academic Validation
  3. Antibacterial Activity of Linezolid against Gram-Negative Bacteria: Utilization of ε-Poly-l-Lysine Capped Silica Xerogel as an Activating Carrier

Antibacterial Activity of Linezolid against Gram-Negative Bacteria: Utilization of ε-Poly-l-Lysine Capped Silica Xerogel as an Activating Carrier

  • Pharmaceutics. 2020 Nov 21;12(11):1126. doi: 10.3390/pharmaceutics12111126.
Gulcihan Guzel Kaya 1 2,  Serena Medaglia 2 3,  Vicente Candela-Noguera 2,  María Ángeles Tormo-Mas 4,  María Dolores Marcos 2 3 5 6,  Elena Aznar 2 3 5 6,  Huseyin Deveci 1,  Ramón Martínez-Máñez 2 3 5 6
Affiliations

Affiliations

  • 1 Department of Chemical Engineering, Konya Technical University, Ardıçlı Mah. Rauf Orbay Cad, Selçuklu, 42250 Konya, Turkey.
  • 2 Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat Politècnica de València, Universitat de València, Camino de Vera s/n, 46022 Valencia, Spain.
  • 3 CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 46022 Valencia, Spain.
  • 4 Grupo Acreditado de Infección Grave, Instituto de Investigación Sanitaria La Fe, Av. Fernando Abril Martorell, 46026 Valencia, Spain.
  • 5 Unidad Mixta de Investigación en Nanomedicina y Sensores, Universitat Politècnica de València, Instituto de Investigación Sanitaria La Fe, Av. Fernando Abril Martorell, 46026 Valencia, Spain.
  • 6 Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, C/Eduardo Primo Yúfera 3, 46100 Valencia, Spain.
PMID: 33233423 DOI: 10.3390/pharmaceutics12111126
Abstract

In recent times, many approaches have been developed against drug resistant Gram-negative bacteria. However, low-cost high effective Materials which could broaden the spectrum of Antibiotics are still needed. In this study, enhancement of linezolid spectrum, normally active against Gram-positive bacteria, was aimed for Gram-negative bacteria growth inhibition. For this purpose, a silica xerogel prepared from a low-cost precursor is used as a drug carrier owing to the advantages of its mesoporous structure, suitable pore and particle size and ultralow density. The silica xerogel is loaded with linezolid and capped with ε-poly-l-lysine. The developed nano-formulation shows a marked Antibacterial activity against to Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. In comparison to free linezolid and ε-poly-l-lysine, the material demonstrates a synergistic effect on killing for the three tested bacteria. The results show that silica xerogels can be used as a potential drug carrier and activity enhancer. This strategy could provide the improvement of Antibacterial activity spectrum of Antibacterial agents like linezolid and could represent a powerful alternative to overcome Antibiotic resistance in a near future.

Keywords

antibacterial activity; linezolid; mesoporous material; silica xerogel; ε-poly-l-lysine.

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