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  3. Engineering micro oxygen factories to slow tumour progression via hyperoxic microenvironments

Engineering micro oxygen factories to slow tumour progression via hyperoxic microenvironments

  • Nat Commun. 2022 Aug 2;13(1):4495. doi: 10.1038/s41467-022-32066-w.
Weili Wang  # 1,  Huizhen Zheng  # 1,  Jun Jiang 1,  Zhi Li 2,  Dongpeng Jiang 3,  Xiangru Shi 3,  Hui Wang 1,  Jie Jiang 1,  Qianqian Xie 1,  Meng Gao 1,  Jianhong Chu 3,  Xiaoming Cai 4,  Tian Xia 5,  Ruibin Li 6
Affiliations

Affiliations

  • 1 State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215123, China.
  • 2 Department of Interventional Radiology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, 215001, China.
  • 3 Institute of Blood and Marrow Transplantation, National Clinical Research Center for Hematologic Diseases, Soochow University, Suzhou, China.
  • 4 School of Public Health, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215123, China.
  • 5 Division of NanoMedicine, Department of Medicine, California Nanosystems Institute, University of California, Los Angeles, CA, 90095, USA.
  • 6 State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215123, China. liruibin@suda.edu.cn.
  • # Contributed equally.
PMID: 35918337 DOI: 10.1038/s41467-022-32066-w
Abstract

While hypoxia promotes carcinogenesis, tumour aggressiveness, metastasis, and resistance to oncological treatments, the impacts of hyperoxia on tumours are rarely explored because providing a long-lasting oxygen supply in vivo is a major challenge. Herein, we construct micro oxygen factories, namely, photosynthesis microcapsules (PMCs), by encapsulation of acquired cyanobacteria and upconversion nanoparticles in alginate microcapsules. This system enables a long-lasting oxygen supply through the conversion of external radiation into red-wavelength emissions for photosynthesis in cyanobacteria. PMC treatment suppresses the NF-kB pathway, HIF-1α production and Cancer cell proliferation. Hyperoxic microenvironment created by an in vivo PMC implant inhibits hepatocarcinoma growth and metastasis and has synergistic effects together with anti-PD-1 in breast Cancer. The engineering oxygen factories offer potential for tumour biology studies in hyperoxic microenvironments and inspire the exploration of oncological treatments.

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