2. Academic Validation
  3. Sex-specific cytotoxicity of ostarine in cardiomyocytes

Sex-specific cytotoxicity of ostarine in cardiomyocytes

  • Mol Cell Endocrinol. 2023 Nov 1:577:112037. doi: 10.1016/j.mce.2023.112037.
Natalia Leciejewska 1,  Ewa Pruszyńska-Oszmałek 2,  Leszek Nogowski 1,  Maciej Sassek 1,  Mathias Z Strowski 3,  Paweł A Kołodziejski 4
Affiliations

Affiliations

  • 1 Department of Animal Physiology, Biochemistry and Biostructure, Poznan University of Life Sciences, 60-637, Poznan, Poland.
  • 2 Department of Animal Physiology, Biochemistry and Biostructure, Poznan University of Life Sciences, 60-637, Poznan, Poland. Electronic address: ewa.pruszynska@up.poznan.pl.
  • 3 Department of Hepatology and Gastroenterology, Charité-University Medicine Berlin, 13353, Berlin, Germany; Medical Clinic III, 15236, Frankfurt (Oder), Germany.
  • 4 Department of Animal Physiology, Biochemistry and Biostructure, Poznan University of Life Sciences, 60-637, Poznan, Poland. Electronic address: pawel.kolodziejski@up.poznan.pl.
PMID: 37543162 DOI: 10.1016/j.mce.2023.112037
Abstract

Ostarine is the most popular compound in the selective Androgen Receptor modulator group (SARMs). Ostarine is used as a physical performance-enhancing agent. The abuse of this agent in higher doses may lead to severe side effects. Here, we evaluate the effects of ostarine on the heart. We utilized a cardiomyocyte H9C2 cell line, isolated primary female and male cardiac fibroblast cells, as well as hearts obtained from rats. Ostarine increased the accumulation of two fibrosis protein markers, αSMA and fibronectin (p < 00.1) in male, but not in female fibroblast cells. Ostarine increased the expression of the cardiomyopathy marker βMhc in the H9C2 cell line (p < 0.05) and in the heart in rats (p < 0.01). The unfavorable changes were observed at high ostarine doses. Moreover, a decrease in viability and an increase in cytotoxicity marker LDH were observed already at lowest dose (1 nmoL/l). Taken together, our results suggest that ostarine is cardiotoxic which may be more relevant in males than in females.

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