2. Academic Validation
  3. TRPV4 in adipose tissue ameliorates diet-induced obesity by promoting white adipocyte browning

TRPV4 in adipose tissue ameliorates diet-induced obesity by promoting white adipocyte browning

  • Transl Res. 2023 Nov 4:S1931-5244(23)00181-0. doi: 10.1016/j.trsl.2023.11.001.
Yan Zhang 1,  Jie Xue 2,  Wenjuan Zhu 3,  Haomin Wang 4,  Pengjiao Xi 5,  Derun Tian 6
Affiliations

Affiliations

  • 1 Department of Clinical Laboratory Diagnostics, Tianjin Medical University, Tianjin 300203, China.
  • 2 Department of Pathology, Handan Central Hospital, Handan, Hebei 057150, China.
  • 3 Department of Nuclear Medicine, Third Hospital of Nanchang, Nanchang, Jiangxi 330008, China.
  • 4 Department of Human Anatomy and Histology, Tianjin Medical University, Tianjin 300070, China.
  • 5 Department of Clinical Laboratory Diagnostics, Tianjin Medical University, Tianjin 300203, China. Electronic address: xipj@tmu.edu.cn.
  • 6 Department of Clinical Laboratory Diagnostics, Tianjin Medical University, Tianjin 300203, China; Department of Human Anatomy and Histology, Tianjin Medical University, Tianjin 300070, China. Electronic address: tiandr@tmu.edu.cn.
PMID: 37926276 DOI: 10.1016/j.trsl.2023.11.001
Abstract

The induction of adipocyte browning to increase energy expenditure is a promising strategy to combat obesity. Transient receptor potential channel V4 (TRPV4) functions as a nonselective cation channel in various cells and plays physiological roles in osmotic and thermal sensations. However, the function of TRPV4 in energy metabolism remains controversial. This study revealed the role of TRPV4 in adipose tissue in the development of obesity. Adipose-specific TRPV4 overexpression protected mice against diet-induced obesity (DIO) and promoted white fat browning. TRPV4 overexpression was also associated with decreased adipose inflammation and improved Insulin sensitivity. Mechanistically, TRPV4 could directly promote white adipocyte browning via the Akt pathway. Consistently, adipose-specific TRPV4 knockout exacerbated DIO with impaired thermogenesis and activated inflammation. Corroborating our findings in mice, TRPV4 expression was low in the white adipose tissue of obese people. Our results positioned TRPV4 as a potential regulator of obesity and energy expenditure in mice and humans.

Keywords

AKT; Adipose; Browning; Diet-induced obesity; TRPV4.

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