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  4. Metabolex-36

Metabolex-36  (Synonyms: Met-36)

目录号: HY-135763
产品使用指南

摩尔计算器

Metabolex-36是由Metabolex（现更名为Cymabay Therapeutics）公司开发的一种FFA4激动剂，在多项研究中用于研究FFA4的功能。Metabolex-36与AstraZeneca公司的化合物（AZ-423和AZ-670）一起用于研究胰腺δ细胞中的FFA4功能。Metabolex-36对FFA4的pEC50值为5.9，而对FFA1的pEC50值小于4.0。Compound B用于研究FFA4在生长激素释放肽（ghrelin）分泌和生长抑素释放中的作用，并与FFA4 KO小鼠一起使用。Compound B在FFA4转染的COS7细胞中的IP3积累实验中对FFA4的EC50为15 nM，对FFA1的选择性高达1000倍。Compound B抑制了来自初级胃黏膜细胞的基线ghrelin分泌，但对来自FFA4 KO小鼠的细胞没有影响。口服Compound B可以降低饥饿条件下的小鼠血浆ghrelin水平。Compound B还抑制了来自初级胃上皮细胞的生长抑素释放，但对来自FFA4 KO小鼠的细胞没有影响。

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Metabolex-36 Chemical Structure

Metabolex-36 Chemical Structure

CAS No. : 1224102-50-4

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Metabolex-36 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Metabolex-36 is a FFA4 agonist developed by Metabolex (now Cymabay Therapeutics) and used in multiple studies to investigate the function of FFA4. Metabolex-36 was used in conjunction with AstraZeneca compounds (AZ-423 and AZ-670) to investigate FFA4 function in pancreatic delta cells. Metabolex-36 has a pEC50 of 5.9 for FFA4 and a pEC50 of less than 4.0 for FFA1. Compound B was used to investigate the role of FFA4 in growth hormone-releasing peptide (ghrelin) secretion and somatostatin release and was used with FFA4 KO mice. Compound B had an EC50 of 15 nM for FFA4 in an IP3 accumulation assay in FFA4-transfected COS7 cells and was up to 1000-fold selective for FFA1. Compound B inhibited baseline ghrelin secretion from primary gastric mucosal cells but had no effect on cells from FFA4 KO mice. Oral administration of Compound B reduced plasma ghrelin levels in mice under starvation conditions. Compound B also inhibited somatostatin release from primary gastric epithelial cells but had no effect on cells from FFA4 KO mice.

分子量

420.84

Formula

C21H19ClF2N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Metabolex-36 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metabolex-361224102-50-4Met-36Metabolex36Metabolex 36Met36Met 36OthersInhibitorinhibitorinhibit

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