1. 多肽产品
  2. 多肽及其衍生物
  3. 激素肽与神经肽
  4. Neuropeptide S (human)

Neuropeptide S (human)  (Synonyms: 神经肽S (人类))

目录号: HY-P1389 纯度: 99.71%
COA 产品使用指南

Neuropeptide S human,一种神经肽,是一种有效的同源神经肽 S 受体 (NPSR) 激动剂。Neuropeptide S human 可用于阿尔茨海默病 (AD) 的研究。

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Custom Peptide Synthesis

Neuropeptide S (human) Chemical Structure

Neuropeptide S (human) Chemical Structure

CAS No. : 412938-67-1

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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Other Forms of Neuropeptide S (human):

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer's disease (AD) research[1].

IC50 & Target

EC50: 9.4 nM (neuropeptide S receptor)[1]

体外研究
(In Vitro)

Half-maximal effective concentrations (EC50) for mobilization of [Ca2+]i are 9.4 nM, 3.2 nM, and 3.0 nM for human, rat, and mouse Neuropeptide S (NPS), respectively[1].
Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC50 of 6.7 nM, the binding of [125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (Kd = 0.33 nM)[1].
Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [125II] Y10-NPS, [125II] Y10-NPS is displaceable by increasing concentrations of human NPS (IC50 = 0.42 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Neuropeptide S human (0.1 nM-1 nM; i.c.v.) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57Bl/6 mice[1]
Dosage: 0.1 nM, 1 nM
Administration: Intracerebroventricular (i.c.v.) injection
Result: Increased locomotor activity and promoted wakefulness.
分子量

2187.48

Formula

C93H155N31O28S

CAS 号
性状

固体

颜色

White to off-white

Sequence

Ser-Phe-Arg-Asn-Gly-Val-Gly-Thr-Gly-Met-Lys-Lys-Thr-Ser-Phe-Gln-Arg-Ala-Lys-Ser

Sequence Shortening

SFRNGVGTGMKKTSFQRAKS

中文名称

神经肽S (人类)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
细胞实验: 

H2O 中的溶解度 : ≥ 50 mg/mL (22.86 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.4571 mL 2.2857 mL 4.5715 mL
5 mM 0.0914 mL 0.4571 mL 0.9143 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.4571 mL 2.2857 mL 4.5715 mL 11.4287 mL
5 mM 0.0914 mL 0.4571 mL 0.9143 mL 2.2857 mL
10 mM 0.0457 mL 0.2286 mL 0.4571 mL 1.1429 mL
15 mM 0.0305 mL 0.1524 mL 0.3048 mL 0.7619 mL
20 mM 0.0229 mL 0.1143 mL 0.2286 mL 0.5714 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Neuropeptide S (human)
目录号:
HY-P1389
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