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OY-201 是一种潜在的可透过血脑屏障的抗缺血性中风剂。OY-201 在体外和体内模型中均显示出良好的安全性和神经保护活性。

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OY-201 Chemical Structure

OY-201 Chemical Structure

CAS No. : 2962943-05-9

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OY-201 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OY-201 is a potential and BBB-penetrated anti-ischemic stroke agent. OY-201 shows the good safety and neuroprotective activity in both in vitro and in vivo models[1].

体内研究
(In Vivo)

OY-201 (10-20 mg/kg, 腹腔注射) 减轻 MCAO 小鼠的脑损伤，并且与sertraline比显示出更高的安全性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (Middle cerebral artery occlusion (MACO)-induced brain infarction model)[1]
Dosage: 10 mg/kg and 20 mg/kg
Administration: IP
Result: Attenuated brain injury of MCAO mice. 10 mg/kg of compound OY-201 reduced the infarcted volume to 13.3% and decreased the neurological severity scores to 1.5. Moreover, treatment with a higher dose of compound OY-201 (20 mg/kg) did not further improve the results, which showed an almost equivalent protective effect. OY-201 at 20 mg/kg significantly ameliorated the mortality of MCAO mice (35.7%) and the survival rate of compound OY-201 was 100% at the dose of 10 mg/kg.
分子量

418.44

Formula

C25H33Cl2N
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

OY-201 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OY-2012962943-05-9OY201OY 201OthersIschemic strokeNeuroprotectionSSRIsSertralineSertraline analoguesblood-brain barrierInhibitorinhibitorinhibit

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HY-149253
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