2. Anti-infection
  3. Bacterial
  4. PA3552-IN-1

PA3552-IN-1 (化合物 15) 是一种抗生素佐剂，可恢复 MDR 铜绿假单胞菌 DK2 菌株对 Polymyxin B 的敏感性。PA3552-IN-1 可以降低 PA3552 的表达。

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PA3552-IN-1 Chemical Structure

PA3552-IN-1 Chemical Structure

CAS No. : 1008121-12-7

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥693
In-stock
5 mg ￥630
In-stock
10 mg ￥1080
In-stock
25 mg ￥2250
In-stock
50 mg ￥3600
In-stock
100 mg ￥5400
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

PA3552-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PA3552-IN-1 (compound 15) is an antibiotic adjuvant that restores sensitivity of MDR P. aeruginosa DK2 strain to Polymyxin B. PA3552-IN-1 can reduce PA3552 expression[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
1.52 μM
Compound: 88
Inhibition of KIX-RLucN fused CBP (unknown origin) binding to KID-RLucC fused CREB (unknown origin) transfected in human HEK293 cells preincubated with compound 30 mins before before forskolin addition and measured after 90 mins in presence of coelenteraz
Inhibition of KIX-RLucN fused CBP (unknown origin) binding to KID-RLucC fused CREB (unknown origin) transfected in human HEK293 cells preincubated with compound 30 mins before before forskolin addition and measured after 90 mins in presence of coelenteraz
[PMID: 31253529]
HL-60 IC50
0.28 μM
Compound: 88
Cytotoxicity against human HL60 cells incubated for 3 days by CellTiter-Glo luminescent assay
Cytotoxicity against human HL60 cells incubated for 3 days by CellTiter-Glo luminescent assay
[PMID: 31253529]
Jurkat IC50
0.53 μM
Compound: 88
Cytotoxicity against human Jurkat cells incubated for 3 days by CellTiter-Glo luminescent assay
Cytotoxicity against human Jurkat cells incubated for 3 days by CellTiter-Glo luminescent assay
[PMID: 31253529]
KG-1 IC50
0.49 μM
Compound: 88
Cytotoxicity against human KG1 cells incubated for 3 days by CellTiter-Glo luminescent assay
Cytotoxicity against human KG1 cells incubated for 3 days by CellTiter-Glo luminescent assay
[PMID: 31253529]
NALM-6 IC50
0.91 μM
Compound: 88
Cytotoxicity against human NALM6 cells incubated for 3 days by CellTiter-Glo luminescent assay
Cytotoxicity against human NALM6 cells incubated for 3 days by CellTiter-Glo luminescent assay
[PMID: 31253529]
Vero C1008 CC50
8.15 μM
Compound: 22
Cytotoxicity against African Green monkey Vero E6 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against African Green monkey Vero E6 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 35344901]
分子量

310.67

Formula

C13H8ClFN2O4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 13.89 mg/mL (44.71 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.2188 mL 16.0942 mL 32.1885 mL
5 mM 0.6438 mL 3.2188 mL 6.4377 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.55%

COA (263 KB) HNMR (277 KB) LCMS (270 KB)

产品使用指南 (1538 KB)
参考文献

PA3552-IN-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2188 mL 16.0942 mL 32.1885 mL 80.4712 mL
5 mM 0.6438 mL 3.2188 mL 6.4377 mL 16.0942 mL
10 mM 0.3219 mL 1.6094 mL 3.2188 mL 8.0471 mL
15 mM 0.2146 mL 1.0729 mL 2.1459 mL 5.3647 mL
20 mM 0.1609 mL 0.8047 mL 1.6094 mL 4.0236 mL
25 mM 0.1288 mL 0.6438 mL 1.2875 mL 3.2188 mL
30 mM 0.1073 mL 0.5365 mL 1.0729 mL 2.6824 mL
40 mM 0.0805 mL 0.4024 mL 0.8047 mL 2.0118 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PA3552-IN-11008121-12-7Bacterialantibiotic adjuvantMDRP. aeruginosaDK2PA3552Inhibitorinhibitorinhibit

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目录号：
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