2. Anti-infection
  3. Bacterial
  4. Proflavine

Proflavine  (Synonyms: 3,6-Diaminoacridine)

目录号: HY-B1741 纯度: 98.78%
COA 产品使用指南

摩尔计算器

Proflavine 是一种吖啶染料，也是一种 DNA 嵌入剂，可用作抗菌剂 (Anti-microbial)。Proflavine 可作为 Kir3.2 孔阻滞剂。Proflavine 可用于研究与 Kir3.2 相关的神经系统疾病。

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Proflavine Chemical Structure

Proflavine Chemical Structure

CAS No. : 92-62-6

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
5 mg ￥630
In-stock
10 mg ￥990
In-stock
25 mg ￥1980
In-stock
50 mg ￥3195
In-stock
100 mg ￥5040
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of Proflavine:

Proflavine 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Proflavine, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent[1]. Proflavine behaves as a pore blocker for Kir3.2. Proflavine is a potential lead compound for Kir3.2-associated neurological diseases[2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 IC50
0.47 μM
Compound: Proflavine
Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs
Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs
[PMID: 9371240]
A2780 IC50
0.47 μM
Compound: Acridine-3,6-diamine
Concentration required to inhibit the cell growth by 50 % after 96 hr A2780 leukemic cells.
Concentration required to inhibit the cell growth by 50 % after 96 hr A2780 leukemic cells.
[PMID: 7658436]
CHO IC50
0.52 μM
Compound: 1
Phototoxicity in transformed CHO cells after 24 hrs of UV irradiation by WST1 assay
Phototoxicity in transformed CHO cells after 24 hrs of UV irradiation by WST1 assay
[PMID: 19217190]
CHO IC50
1.1 μM
Compound: 1
Phototoxicity in transformed CHO cells after 24 hrs incubation in dark by WST1 assay
Phototoxicity in transformed CHO cells after 24 hrs incubation in dark by WST1 assay
[PMID: 19217190]
Keratinocyte IC50
> 50 μM
Compound: 1
Phototoxicity in normal human keratinocytes after 24 hrs incubation in dark by WST1 assay
Phototoxicity in normal human keratinocytes after 24 hrs incubation in dark by WST1 assay
[PMID: 19217190]
Keratinocyte IC50
> 50 μM
Compound: 1
Phototoxicity in normal human keratinocytes after 24 hrs of UV irradiation by WST1 assay
Phototoxicity in normal human keratinocytes after 24 hrs of UV irradiation by WST1 assay
[PMID: 19217190]
L1210 IC50
2.7 μM
Compound: Proflavine
Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs
Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs
[PMID: 9371240]
L1210 IC50
2.7 μM
Compound: Acridine-3,6-diamine
Concentration required to inhibit the cell growth by 50 % after 48 hr in L1210 leukemic cells.
Concentration required to inhibit the cell growth by 50 % after 48 hr in L1210 leukemic cells.
[PMID: 7658436]
Clinical Trial
分子量

209.25

Formula

C13H11N3
CAS 号
性状

固体

颜色

Yellow to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (597.37 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.7790 mL 23.8949 mL 47.7897 mL
5 mM 0.9558 mL 4.7790 mL 9.5579 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Proflavine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7790 mL 23.8949 mL 47.7897 mL 119.4743 mL
5 mM 0.9558 mL 4.7790 mL 9.5579 mL 23.8949 mL
10 mM 0.4779 mL 2.3895 mL 4.7790 mL 11.9474 mL
15 mM 0.3186 mL 1.5930 mL 3.1860 mL 7.9650 mL
20 mM 0.2389 mL 1.1947 mL 2.3895 mL 5.9737 mL
25 mM 0.1912 mL 0.9558 mL 1.9116 mL 4.7790 mL
30 mM 0.1593 mL 0.7965 mL 1.5930 mL 3.9825 mL
40 mM 0.1195 mL 0.5974 mL 1.1947 mL 2.9869 mL
50 mM 0.0956 mL 0.4779 mL 0.9558 mL 2.3895 mL
60 mM 0.0796 mL 0.3982 mL 0.7965 mL 1.9912 mL
80 mM 0.0597 mL 0.2987 mL 0.5974 mL 1.4934 mL
100 mM 0.0478 mL 0.2389 mL 0.4779 mL 1.1947 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Proflavine92-62-63,6-DiaminoacridineBacterialWholebloodG proteingatedinwardrectifierK+channelInhibitorinhibitorinhibit

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