2. Anti-infection Membrane Transporter/Ion Channel Autophagy
  3. Bacterial Potassium Channel Autophagy
  4. Proflavine hemisulfate

Proflavine hemisulfate  (Synonyms: 硫酸原黄素; Proflavin hemisulfate; 3,6-Diaminoacridine hemisulfate)

目录号: HY-B0883 纯度: 98.45%
COA 产品使用指南

摩尔计算器

Proflavine hemisulfate 是一种吖啶染料，也是一种 DNA嵌入剂。可用作抗菌剂 (Anti-microbial)。Proflavine hemisulfate 可作为 Kir3.2 孔阻滞剂。Proflavine hemisulfate 可用于研究与 Kir3.2 相关的神经系统疾病。

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Proflavine hemisulfate Chemical Structure

Proflavine hemisulfate Chemical Structure

CAS No. : 1811-28-5

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥550
In-stock
100 mg ￥500
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of Proflavine hemisulfate:

Proflavine hemisulfate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Proflavine hemisulfate, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent[1]. Proflavine hemisulfate behaves as a pore blocker for Kir3.2. Proflavine hemisulfate is a potential lead compound for Kir3.2-associated neurological diseases[2].

体外研究
(In Vitro)

Proflavine (0.1-10 μM; 24 hours) inhibits the growth of Kir3.2-transformant cells and Kir3.2 activity in a concentration-dependent manner[1].
Proflavine (300 μM) progressively reduces the current amplitude of Kir3.2 mutant to 27.7±4.3% of the control[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Proflavine hemisulfate 相关抗体:

Cell Viability Assay[2]

Cell Line: Kir3.2*-transformant BYT123 cells
Concentration: 0.1, 1, and 10 μM
Incubation Time: 24 hours
Result: Dose-dependent inhibition of the growth of Kir3.2*-transformant cells.
Attenuated the growth of Kir3.2*-transformant cells without affecting the growth of control cells.
体内研究
(In Vivo)

The concentrations of Proflavine (20 mg/kg) in whole blood after intravenous injection decreased rapidly at the beginning and remained stable from around 30 min after dosing[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague Dawley rats (weighing approximately 200 g)[3]
Dosage: 20 mg/kg (Pharmacokinetic Analysis)
Administration: Intravenous injection; 2, 4, 5, 10, 15, 20, 25, and 30 min after dosing
Result: Concentration decreased rapidly from whole blood in the first 5 min after dosing, followed by a slower decrease.
Clinical Trial
分子量

258.28

Formula

C13H11N3.1/2H2SO4
CAS 号
性状

固体

颜色

Brown to reddish brown

中文名称

硫酸原黄素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 16.67 mg/mL (64.54 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : ≥ 5 mg/mL (19.36 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.8718 mL 19.3588 mL 38.7177 mL
5 mM 0.7744 mL 3.8718 mL 7.7435 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.45%

COA (286 KB) LCMS (86 KB)

产品使用指南 (1538 KB)
参考文献

Proflavine hemisulfate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.8718 mL 19.3588 mL 38.7177 mL 96.7942 mL
5 mM 0.7744 mL 3.8718 mL 7.7435 mL 19.3588 mL
10 mM 0.3872 mL 1.9359 mL 3.8718 mL 9.6794 mL
15 mM 0.2581 mL 1.2906 mL 2.5812 mL 6.4529 mL
DMSO 20 mM 0.1936 mL 0.9679 mL 1.9359 mL 4.8397 mL
25 mM 0.1549 mL 0.7744 mL 1.5487 mL 3.8718 mL
30 mM 0.1291 mL 0.6453 mL 1.2906 mL 3.2265 mL
40 mM 0.0968 mL 0.4840 mL 0.9679 mL 2.4199 mL
50 mM 0.0774 mL 0.3872 mL 0.7744 mL 1.9359 mL
60 mM 0.0645 mL 0.3226 mL 0.6453 mL 1.6132 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Proflavine hemisulfate1811-28-5Proflavin hemisulfate 3,6-Diaminoacridine hemisulfate硫酸原黄素BacterialPotassium ChannelAutophagyKcsAWholebloodG proteingatedinwardrectifierK+channelInhibitorinhibitorinhibit

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