ACP5 蛋白, Human (HEK293, His)

The ACP5 protein actively dephosphorylates osteopontin and bone sialoprotein. Its upregulated expression in pathological conditions like Gaucher and Hodgkin diseases, hairy cell, B-cell, and T-cell leukemias suggests a potential association with these diseases. This underscores ACP5's relevance in diverse pathological states, indicating its role in modulating pathways related to bone health and hematopoietic system disorders. ACP5 Protein, Human (HEK293, His) is the recombinant human-derived ACP5 protein, expressed by HEK293 , with C-His labeled tag. The total length of ACP5 Protein, Human (HEK293, His) is 299 a.a., with molecular weight of ~35 kDa.

ACP5 蛋白积极参与骨桥蛋白和骨唾液蛋白的去磷酸化。值得注意的是，其表达似乎在特定病理条件下上调，包括戈谢病和霍奇金病，以及毛细胞、B 细胞和 T 细胞白血病。这表明 ACP5 表达与这些病理状态之间存在潜在关联，表明其与多种疾病的相关性。ACP5 参与与骨代谢相关的关键蛋白的去磷酸化，凸显了其在调节与骨健康和影响造血系统的病理状况相关的途径中的作用。

Measured by its ability to cleave a substrate, p-Nitrophenyl phosphate (pNPP). The specific activity is 37780 pmoL/min/μg.

Human

HEK293

C-His

P13686 (A22-P320)

54  [NCBI]

ATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSKEMTVTYIEASGKSLFKTRLP

Approximately 35 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.