CADM4/IGSF4C 蛋白, Human (HEK293, His)

CADM4/IGSF4C Protein is crucial for calcium- and magnesium-independent cell-cell adhesion, actively mediating cellular interactions. Apart from its adhesive role, it is speculated to act as a tumor suppressor, hinting at a potential regulatory role in cell growth and tumorigenic processes. The dual attributes of mediating adhesion and potentially suppressing tumors highlight the multifaceted nature of CADM4/IGSF4C in cellular processes. CADM4/IGSF4C Protein, Human (HEK293, His) is the recombinant human-derived CADM4/IGSF4C protein, expressed by HEK293 , with C-His labeled tag.

CADM4/IGSF4C 蛋白在细胞间粘附中发挥着至关重要的作用，表现出不依赖于钙和镁的粘附活性。这种蛋白质以其单体和同二聚体形式积极参与介导细胞相互作用。除了其粘附功能外，CADM4/IGSF4C 还被推测具有肿瘤抑制活性，这表明在调节细胞生长和抑制致瘤过程中具有潜在作用。介导细胞间粘附和潜在发挥肿瘤抑制作用的双重属性强调了 CADM4/IGSF4C 在细胞过程中的多方面性质。

Measured by its ability to inhibit the proliferation of A549 cells. The ED₅₀ for this effect is 0.4653 μg/mL, corresponding to a specific activity is 2.149×10³ units/mg.

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  Measured by its ability to inhibit the proliferation of A549 cells. The ED₅₀ for this effect is 0.4653 μg/mL, corresponding to a specific activity is 2.149×10³ units/mg.

Human

HEK293

C-6*His

Q8NFZ8 (P21-Y323)

199731  [NCBI]

PGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPY

Approximately 48-70 kDa.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.