CD2 蛋白, Canine (HEK293, His)

CD2 Protein is a cell surface glycoprotein that is expressed on the surface of T cells, NK cells, thymus cells and dendritic cells. The CD2 Protein mediates the adhesion of T cells to various cell types and triggers T cell responses through interactions with lymphocyte function-related antigens CD58 (LFA-3) and CD48/BCM1. CD2 Protein, Canine (HEK293, His) is the recombinant canine-derived CD2 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD2 Protein, Canine (HEK293, His) is 183 a.a., with molecular weight of 35-45 kDa.

CD2 是一种细胞表面糖蛋白，在 T 细胞、NK 细胞、胸腺细胞和树突状细胞表面表达。通过与淋巴细胞功能相关抗原 CD58 (LFA-3) 和 CD48/BCM1 的相互作用，在介导 T 细胞与各种细胞类型的粘附中起着至关重要的作用。除了粘附功能外，CD2 还参与触发 T 细胞反应，其细胞质结构域在信号通路中发挥作用。该蛋白与 CD48、CD58 (LFA-3)、CD2AP 和PSTPIP1 相互作用，形成一个复杂的分子相互作用网络。此外，CD2 和 FCGR3A 之间的相互作用调节 NK 细胞的活化和细胞毒性，突出了其在免疫细胞功能中的多种参与。

Canine

HEK293

C-6*His

XP_849219.1 (E22-D204)

607448  [NCBI]

EVLETKLVWGALGHDFDLDSAGFQMNAKIDHIRWEKGKTKVAELKTGILKDTHGKYNISTNGFLKIKHLMMNDSDIYKVAIYDKDGKSVLRRNYQLKIQEKVSTPKILWSCGNQSLTCEITSGTDPTLMLYVNQTMIKNLLNMTIVQWNWTSQQEMTVSCTAKNEVSQKREEKIINCSEKGLD

Approximately 35-45 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.