2. 重组蛋白
  3. Immune Checkpoint Proteins CD Antigens
  4. Inhibitory Checkpoint Molecules NK Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Cell Adhesion-related CD Proteins
  5. CD96
  6. CD96 蛋白, Human (C110S, HEK293, His)

CD96 蛋白, Human (C110S, HEK293, His)

目录号: HY-P78660
产品使用指南

CD96 促进免疫反应后期激活的 T 细胞和 NK 细胞的粘附相互作用。它通过与靶细胞上的 PVR 相互作用，促进 NK 细胞与靶细胞之间的粘附。这种相互作用发生在 T 细胞和 NK 细胞利用整合素和选择素穿透内皮细胞后，主动与炎症区域内的患病细胞接触。 CD96 形成通过二硫键连接的同二聚体并与 PVR 相互作用。CD96 蛋白, Human (C110S, HEK293, His) 是重组的 CD96 蛋白，由 HEK293 表达，带有 C-His 标签和 C110S 突变。CD96 蛋白, Human (C110S, HEK293, His) 全长 482 个氨基酸，分子量为 100-130 kDa。

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描述

CD96 facilitates adhesive interactions of activated T and NK cells in the late phase of the immune response. It promotes adhesion between NK cells and target cells by interacting with PVR on the target cells. This interaction occurs after T and NK cells have penetrated the endothelium using integrins and selectins, actively engaging diseased cells within areas of inflammation. CD96 forms homodimers linked by disulfide bonds and interacts with PVR. CD96 Protein, Human (C110S, HEK293, His) is the recombinant human-derived CD96 protein, expressed by HEK293 , with C-His labeled tag and C110S mutation. The total length of CD96 Protein, Human (C110S, HEK293, His) is 482 a.a., with molecular weight of 100-130 kDa.
研究背景

CD96 蛋白似乎在免疫反应后期的粘附相互作用中发挥作用，可能涉及活化的 T 细胞和 NK 细胞。它通过与靶细胞上存在的 PVR 相互作用来促进 NK 细胞与靶标的粘附。 CD96 可能在 T 细胞和 NK 细胞使用整合素和选择素穿透内皮细胞后的一个阶段发挥作用，积极与病变细胞结合并在炎症区域内导航。在结构上，CD96 通过二硫键形成同二聚体，并与 PVR 特异性相互作用，表明它参与了炎症和感染期间免疫反应至关重要的细胞间相互作用。
种属

Human
表达系统

HEK293
标签

C-His
蛋白编号

P40200-2 (V22-M503, C110S)
基因 ID
蛋白结构
N-term
CD96 (V22-M503, C110S)
Accession # P40200-2
His
C-term
同用名
T-cell surface protein tactile; Cell surface antigen CD96; CD96
分子量

100-130 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<0.1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CD96 Protein, Human (C110S, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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