CEACAM1 蛋白, Mouse (HEK293, His)

The CEACAM1 protein is a cell adhesion molecule that mediates calcium-independent homologous cell adhesion. CEACAM1 negatively regulates neutrophil and platelet function, downregulates the CSF3R-STAT3 pathway, and modulates insulin clearance and lipogenesis. CEACAM1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CEACAM1 protein, expressed by HEK293 , with C-His labeled tag.

CEACAM1 蛋白作为细胞粘附分子，以不依赖于钙的方式介导同质细胞粘附。它作为免疫反应和胰岛素作用中的共抑制受体发挥多方面的作用，同时也在血管生成过程中充当激活剂。通过磷酸化和 PTPN6 依赖性机制，CEACAM1 抑制相关受体的信号转导，抑制 T 细胞的细胞毒性、增殖和细胞因子的产生。此外，它还通过与HAVCR2相互作用来调节自身免疫和抗肿瘤免疫。在 NK 细胞中，它抑制 KLRK1 介导的细胞溶解并负向调节中性粒细胞中 IL1B 的产生。CEACAM1 通过充当 CSF3R 的共抑制受体来下调中性粒细胞的产生，并且还通过促进 INS 清除和控制肝脏中的脂肪生成来调节胰岛素作用。此外，它还充当血管生成的激活剂，促进血管重塑和动脉生成。CEACAM1 调节血管通透性，下调 EGF 反应的细胞生长，抑制血小板聚集，负向调节破骨细胞生成，并有助于调节与微生物群控制和抵抗肠道病原体相关的 IgA 产生和分泌。

Mouse

HEK293

C-His

P31809-1 (E35-G428)

26365  [NCBI]

75-110 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.