Clumping factor B 蛋白, S. aureus (His)

Clumping factor B (ClfB) is a cell surface-associated protein implicated in virulence, playing a crucial role in bacterial pathogenicity by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen. Its significance lies in inducing the formation of bacterial clumps, a mechanism that contributes to the pathogenicity and virulence of the bacteria. Clumping factor B Protein, S. aureus (His) is the recombinant Staphylococcus aureus-derived Clumping factor B protein, expressed by E. coli , with N-His labeled tag. The total length of Clumping factor B Protein, S. aureus (His) is 498 a.a., with molecular weight of ~80 kDa.

聚集因子 B (ClfB) 是一种对细菌毒力至关重要的细胞表面相关蛋白，因为它在促进细菌附着方面发挥着关键作用。它特异性结合人纤维蛋白原的α链和β链，促进细菌团块的形成。这种相互作用在宿主与病原体相互作用的背景下非常重要，因为它增强了细菌对纤维蛋白原的粘附，从而有助于生物体的致病性。ClfB 诱导细菌团块的能力表明它参与了感染的早期阶段，并强调了它作为旨在破坏细菌粘附和毒力的治疗干预目标的潜力（参考：提供的信息）。

Staphylococcus aureus

E. coli

N-His

Q6GDH2 (S45-N542)

/

SEQSNDTTQSSKNNASADSEKNNTIETPQLNTTANDTSDISANTNSANVDSTAKTMSTQTSNTTTTEPASTNETPQPTAIKDQATAAKMQDQTVPQEANSQVDNKTTNDANNIATNSELKNPQTLDLPQSSPQTISNAQGTSKPSVRTRAVRSLAVAEPVVNAADAKGTNVNDKVTASDFKLEKTAFDPNQSGNTFMAANFKVTGQVKSGDYFTAKLPDSVTGNGDVDYSNSNNTMPIADIKSTNGDVVAKATYDILTKTYTFVFTDYVNDKENINGQFSLPLFTDRAKAPKSGTYDANINIADEMFDNKITYNYSSPIAGIDKPNGANISSQIIGVDTASGQNTYKQTVFVNPKQRVLGNTWVYIKGYQDKIEESSGKVSATDTKLRIFEVNDTSKLSDSYYADPNDSNLKEVTGEFKDKISYKYDNVASINFGDINKTYVVLVEGHYDNTGKNLKTQVIQENIDPATGKDYSIFGWNNENVVRYGGGSADGDSAVN

Approximately 80 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4.

<1.0 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.