CROT 蛋白, Human (V474L, sf9, His)

CROT protein is critical in the β-oxidation process, showing the highest enzymatic activity on C6 to C10 substrates. As a key player in lipid metabolism, CROT promotes the conversion of 4,8-dimethylnonanoyl-CoA to its carnitine ester, regulating fatty acid oxidation to achieve cellular energy balance. CROT Protein, Human (V474L, sf9, His) is the recombinant human-derived CROT protein, expressed by Sf9 insect cells , with C-His labeled tag and V474L mutation.

CROT 蛋白在脂肪酸的 β 氧化中发挥着关键作用，对链长范围为 C6 至 C10 的底物表现出最高的酶活性。作为脂质代谢的关键参与者，CROT 促进降植烷酸 β-氧化的最终产物（即 4,8-二甲基壬酰辅酶 A）转化为其相应的肉碱酯。这种酶促过程对于调节脂肪酸氧化平衡至关重要，有助于细胞能量稳态。了解 CROT 的具体活动可以深入了解控制脂肪酸分解代谢的复杂机制，对代谢调节和能量产生具有潜在影响。对 CROT 功能的进一步研究有望增进我们对脂质代谢的理解，并可能为代谢紊乱的治疗干预提供途径。

Human

Sf9 insect cells

C-His

Q9UKG9-1 (M1-L612, V474L)

54677  [NCBI]

Approximately 65 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.