CSAD 蛋白, Mouse (His-SUMO)

CSAD proteins play a crucial role in the metabolism of sulfur-containing amino acids, catalyzing L-aspartate, 3-sulfinyl-L-alanine (cysteine sulfenic acid) and L-cysteine The acid is decarboxylated to produce β-alanine, hypotaurine and taurine respectively. Among these substrates, 3-sulfinyl-L-alanine is the preferred substrate for CSAD. CSAD Protein, Mouse (His-SUMO) is the recombinant mouse-derived CSAD protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of CSAD Protein, Mouse (His-SUMO) is 493 a.a., with molecular weight of ~71.1 kDa.

半胱氨酸亚磺酸脱羧酶 (CSAD) 是一种催化三种底物脱羧的酶：L-天冬氨酸、3-亚磺基-L-丙氨酸（半胱氨酸亚磺酸）和 L-半胱氨酸，从而产生 β-丙氨酸、亚牛磺酸，和牛磺酸，分别。在这些底物中，CSAD 显示出对 3-亚磺基-L-丙氨酸的偏好。值得注意的是，该酶不表现出任何针对谷氨酸的脱羧活性。CSAD 的多种底物特异性表明它参与重要代谢物的生物合成，例如牛磺酸和 β-丙氨酸，这些代谢物在各种生理过程中发挥作用，包括胆汁盐形成和神经传递。参考文献强调了 CSAD 选择性地使特定底物脱羧的能力，阐明了其在含硫氨基酸细胞代谢中的重要性。

Mouse

E. coli

N-6*His;N-SUMO

Q9DBE0 (M1-L493)

246277  [NCBI]

MADSKPLRTLDGDPVAVEALLQDVFGIVVDEAILKGTSASEKVCEWKEPEELKQLLDLELQSQGESREQILERCRTVIHYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGWNSGDGVFCPGGSISNMYAMNLARFQRYPDCKQRGLRALPPLALFTSKECHYSITKGAAFLGLGTDSVRVVKADERGRMIPEDLERQIILAEAEGSVPFLVSATSGTTVLGAFDPLDAIADVCQRHGLWFHVDAAWGGSVLLSRTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLRDTSNLLKRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGGQGLERRIDQAFALTRYLVEEIKKREGFELVMEPEFVNVCFWFVPPSLRGKKESPDYSQRLSQVAPVLKERMVKKGTMMIGYQPHGTRANFFRMVVANPILAQADIDFLLGELELLGQDL

Approximately 71.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.