EphB4 蛋白, Human (HEK293, His)

EphB4 protein is a receptor tyrosine kinase that binds to ephrin B ligand and initiates bidirectional signaling. Positive signaling regulates the rejection and separation of cells from EFNB2-expressing cells. EphB4 Protein, Human (HEK293, His) is the recombinant human-derived EphB4 protein, expressed by HEK293 , with C-His labeled tag.

EphB4 蛋白是一种受体酪氨酸激酶，与位于相邻细胞上的跨膜肝配蛋白 B 家族配体混杂结合，启动接触依赖性双向信号传导。源自受体的下游途径称为正向信号传导，而肝配蛋白配体下游的信号传导途径称为反向信号传导。EphB4 与其同源配体 EFNB2 合作，复杂地参与调节细胞粘附和迁移。此外，EphB4 在心脏形态发生、血管生成以及血管重塑和通透性中发挥着核心作用。EPHB4 介导的正向信号传导有助于控制细胞排斥和与表达 EFNB2 的细胞的分离。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-His

P54760-1/NP_004435.3 (L16-A539)

2050  [NCBI]

60-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.